Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling

G protein–coupled receptors (GPCRs) exist in multiple dynamic states (e.g., ligand-bound, inactive, G protein–coupled) that influence G protein activation and ultimately response generation. In quantitative models of GPCR signaling that incorporate these varied states, parameter values are often unc...

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Detalles Bibliográficos
Autores principales: Kinzer-Ursem, Tamara L, Linderman, Jennifer J
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769407/
https://www.ncbi.nlm.nih.gov/pubmed/17222056
http://dx.doi.org/10.1371/journal.pcbi.0030006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769407/
https://www.ncbi.nlm.nih.gov/pubmed/17222056
http://dx.doi.org/10.1371/journal.pcbi.0030006

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