A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism

BACKGROUND: HIV protease inhibitor (PI) therapy results in the rapid selection of drug resistant viral variants harbouring one or two substitutions in the viral protease. To combat PI resistance development, two approaches have been developed. The first is to increase the level of PI in the plasma o...

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Detalles Bibliográficos
Autores principales: Nijhuis, Monique, van Maarseveen, Noortje M, Lastere, Stephane, Schipper, Pauline, Coakley, Eoin, Glass, Bärbel, Rovenska, Mirka, de Jong, Dorien, Chappey, Colombe, Goedegebuure, Irma W, Heilek-Snyder, Gabrielle, Dulude, Dominic, Cammack, Nick, Brakier-Gingras, Lea, Konvalinka, Jan, Parkin, Neil, Kräusslich, Hans-Georg, Brun-Vezinet, Francoise, Boucher, Charles A. B
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769415/
https://www.ncbi.nlm.nih.gov/pubmed/17227139
http://dx.doi.org/10.1371/journal.pmed.0040036

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