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Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI) of the spine shows areas of bone marrow edema, the histopathological equivalent of which is unknown. In this st...

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Autores principales: Appel, Heiner, Loddenkemper, Christoph, Grozdanovic, Zarko, Ebhardt, Harald, Dreimann, Marc, Hempfing, Axel, Stein, Harald, Metz-Stavenhagen, Peter, Rudwaleit, Martin, Sieper, Joachim
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779434/
https://www.ncbi.nlm.nih.gov/pubmed/16925803
http://dx.doi.org/10.1186/ar2035
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author Appel, Heiner
Loddenkemper, Christoph
Grozdanovic, Zarko
Ebhardt, Harald
Dreimann, Marc
Hempfing, Axel
Stein, Harald
Metz-Stavenhagen, Peter
Rudwaleit, Martin
Sieper, Joachim
author_facet Appel, Heiner
Loddenkemper, Christoph
Grozdanovic, Zarko
Ebhardt, Harald
Dreimann, Marc
Hempfing, Axel
Stein, Harald
Metz-Stavenhagen, Peter
Rudwaleit, Martin
Sieper, Joachim
author_sort Appel, Heiner
collection PubMed
description Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI) of the spine shows areas of bone marrow edema, the histopathological equivalent of which is unknown. In this study we correlate inflammation in the spine of patients with AS as revealed by histological examination with bone marrow edema as detected by MRI. We have compared the histopathological findings of zygapophyseal joints from 8 patients with AS (age: 30 to 64, disease duration 7 to 33 years) undergoing spinal surgery with findings in MRI. For histopathological analysis, we quantified infiltrates of CD3+, CD4+ and CD8+ T cells as well as CD20+ B cells immunohistochemically. Bone marrow edema was evaluated in hematoxylin and eosin stained sections and quantified as the percentage of the bone marrow area involved. All patients with AS showed interstitial mononuclear cell infiltrates and various degrees of bone marrow edema (range from 10% to 60%) in histopathological analysis. However, in only three of eight patients histopathological inflammation and edema in the zygapophyseal joints correlated with bone marrow edema in zygapophyseal joints of the lumbar spine as detected by MRI. Interestingly, two of these patients showed the highest histological score for bone marrow edema (60%). This first study correlating histopathological changes in the spine of patients with AS with findings in MRI scans suggests that a substantial degree of bone marrow inflammation and edema is necessary to be detected by MRI.
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spelling pubmed-17794342007-01-19 Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis Appel, Heiner Loddenkemper, Christoph Grozdanovic, Zarko Ebhardt, Harald Dreimann, Marc Hempfing, Axel Stein, Harald Metz-Stavenhagen, Peter Rudwaleit, Martin Sieper, Joachim Arthritis Res Ther Research Article Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI) of the spine shows areas of bone marrow edema, the histopathological equivalent of which is unknown. In this study we correlate inflammation in the spine of patients with AS as revealed by histological examination with bone marrow edema as detected by MRI. We have compared the histopathological findings of zygapophyseal joints from 8 patients with AS (age: 30 to 64, disease duration 7 to 33 years) undergoing spinal surgery with findings in MRI. For histopathological analysis, we quantified infiltrates of CD3+, CD4+ and CD8+ T cells as well as CD20+ B cells immunohistochemically. Bone marrow edema was evaluated in hematoxylin and eosin stained sections and quantified as the percentage of the bone marrow area involved. All patients with AS showed interstitial mononuclear cell infiltrates and various degrees of bone marrow edema (range from 10% to 60%) in histopathological analysis. However, in only three of eight patients histopathological inflammation and edema in the zygapophyseal joints correlated with bone marrow edema in zygapophyseal joints of the lumbar spine as detected by MRI. Interestingly, two of these patients showed the highest histological score for bone marrow edema (60%). This first study correlating histopathological changes in the spine of patients with AS with findings in MRI scans suggests that a substantial degree of bone marrow inflammation and edema is necessary to be detected by MRI. BioMed Central 2006 2006-08-22 /pmc/articles/PMC1779434/ /pubmed/16925803 http://dx.doi.org/10.1186/ar2035 Text en Copyright © 2006 Appel et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Appel, Heiner
Loddenkemper, Christoph
Grozdanovic, Zarko
Ebhardt, Harald
Dreimann, Marc
Hempfing, Axel
Stein, Harald
Metz-Stavenhagen, Peter
Rudwaleit, Martin
Sieper, Joachim
Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis
title Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis
title_full Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis
title_fullStr Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis
title_full_unstemmed Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis
title_short Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis
title_sort correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779434/
https://www.ncbi.nlm.nih.gov/pubmed/16925803
http://dx.doi.org/10.1186/ar2035
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