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Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants

INTRODUCTION: Tamoxifen (TAM) is an antiestrogen widely used in the treatment and prevention of breast cancer in women. One of the major mechanisms of metabolism of TAM and one of its major active metabolites, 4-hydroxytamoxifen (4-OH-TAM), is via glucuronidation. In the present study, the glucuroni...

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Detalles Bibliográficos
Autores principales:	Sun, Dongxiao, Chen, Gang, Dellinger, Ryan W, Duncan, Kimberly, Fang, Jia-Long, Lazarus, Philip
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779459/ https://www.ncbi.nlm.nih.gov/pubmed/16884532 http://dx.doi.org/10.1186/bcr1539

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