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The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

INTRODUCTION: Loss of the cyclin-dependent kinase inhibitor p27 is associated with poor prognosis in breast cancer. The decrease in p27 levels is mainly the result of enhanced proteasome-dependent degradation mediated by its specific ubiquitin ligase subunit S phase kinase protein 2 (Skp2). The mamm...

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Detalles Bibliográficos
Autores principales:	Shapira, Ma'anit, Kakiashvili, Eli, Rosenberg, Tzur, Hershko, Dan D
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779462/ https://www.ncbi.nlm.nih.gov/pubmed/16859513 http://dx.doi.org/10.1186/bcr1533

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