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The high frequency of manic symptoms in fibromyalgia does influence the choice of treatment?
BACKGROUND: Mood disorders were found associated with fibromyalgia (FM) and clinical studies have revealed the efficacy of antidepressant drugs in the treatment of FM. However no specific instruments to identify manic symptoms were used. OBJECTIVES: To assess the frequency of anxiety and mood disord...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779782/ https://www.ncbi.nlm.nih.gov/pubmed/17177985 http://dx.doi.org/10.1186/1745-0179-2-36 |
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author | Carta, Mauro Giovanni Cardia, Claudia Mannu, Francesca Intilla, Gesuina Hardoy, Maria Carolina Anedda, C Ruggero, V Fornasier, D Cacace, Enrico |
author_facet | Carta, Mauro Giovanni Cardia, Claudia Mannu, Francesca Intilla, Gesuina Hardoy, Maria Carolina Anedda, C Ruggero, V Fornasier, D Cacace, Enrico |
author_sort | Carta, Mauro Giovanni |
collection | PubMed |
description | BACKGROUND: Mood disorders were found associated with fibromyalgia (FM) and clinical studies have revealed the efficacy of antidepressant drugs in the treatment of FM. However no specific instruments to identify manic symptoms were used. OBJECTIVES: To assess the frequency of anxiety and mood disorders (particularly bipolar disorders and manic symptoms) in a consecutive sample of women affected by FM using standardized diagnostic tools and to compare the prevalence of these disorders with that observed in a sample of healthy controls from the general population. METHODS: Cases: consecutive series of women (N = 37, mean age 50.1 ± 21.0) attending a Rheumatology outpatient Unit at the University of Cagliari. Controls: 148 women, drawn from the data bank of an epidemiological study matched for sex and age with controls according to a randomisation "after blocks" method. The Italian version of the Composite International Diagnostic Interview Simplified were carried out by physicians. Psychiatric diagnosis was formulated according to DSM-IV criteria. The Italian version of the Mood Disorder Questionnaire (MDQ) was administered to identify manic symptoms and bipolar disorders. Diagnosis of FM were carried out by rheumatologist according to the criteria of American College of Rheumatology. RESULTS: Subjects with FM showed a higher comorbidity with Generalised Anxiety Disorder, Panic Disorder and Major Depressive Disorder than controls. The study showed a high frequency of manic symptoms (MDQ positive) in the sample of fibromyalgic patients (59%), approximately double that found in the control sample (P < 0.001). DISCUSSION: Clinical studies have shown the efficacy of antidepressants, especially tricyclic antidepressants, in the treatment of FM. The clinical difficulty in identifying hypomanic episodes is well known particularly where previous and not present episodes are concerned as in depressive patients. These data would suggest further studies on the subject are needed and more caution also in prescribing antidepressants in a population apparently at high risk for bipolar disorders. |
format | Text |
id | pubmed-1779782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-17797822007-01-20 The high frequency of manic symptoms in fibromyalgia does influence the choice of treatment? Carta, Mauro Giovanni Cardia, Claudia Mannu, Francesca Intilla, Gesuina Hardoy, Maria Carolina Anedda, C Ruggero, V Fornasier, D Cacace, Enrico Clin Pract Epidemiol Ment Health Research BACKGROUND: Mood disorders were found associated with fibromyalgia (FM) and clinical studies have revealed the efficacy of antidepressant drugs in the treatment of FM. However no specific instruments to identify manic symptoms were used. OBJECTIVES: To assess the frequency of anxiety and mood disorders (particularly bipolar disorders and manic symptoms) in a consecutive sample of women affected by FM using standardized diagnostic tools and to compare the prevalence of these disorders with that observed in a sample of healthy controls from the general population. METHODS: Cases: consecutive series of women (N = 37, mean age 50.1 ± 21.0) attending a Rheumatology outpatient Unit at the University of Cagliari. Controls: 148 women, drawn from the data bank of an epidemiological study matched for sex and age with controls according to a randomisation "after blocks" method. The Italian version of the Composite International Diagnostic Interview Simplified were carried out by physicians. Psychiatric diagnosis was formulated according to DSM-IV criteria. The Italian version of the Mood Disorder Questionnaire (MDQ) was administered to identify manic symptoms and bipolar disorders. Diagnosis of FM were carried out by rheumatologist according to the criteria of American College of Rheumatology. RESULTS: Subjects with FM showed a higher comorbidity with Generalised Anxiety Disorder, Panic Disorder and Major Depressive Disorder than controls. The study showed a high frequency of manic symptoms (MDQ positive) in the sample of fibromyalgic patients (59%), approximately double that found in the control sample (P < 0.001). DISCUSSION: Clinical studies have shown the efficacy of antidepressants, especially tricyclic antidepressants, in the treatment of FM. The clinical difficulty in identifying hypomanic episodes is well known particularly where previous and not present episodes are concerned as in depressive patients. These data would suggest further studies on the subject are needed and more caution also in prescribing antidepressants in a population apparently at high risk for bipolar disorders. BioMed Central 2006-12-19 /pmc/articles/PMC1779782/ /pubmed/17177985 http://dx.doi.org/10.1186/1745-0179-2-36 Text en Copyright ©2006 Carta et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Carta, Mauro Giovanni Cardia, Claudia Mannu, Francesca Intilla, Gesuina Hardoy, Maria Carolina Anedda, C Ruggero, V Fornasier, D Cacace, Enrico The high frequency of manic symptoms in fibromyalgia does influence the choice of treatment? |
title | The high frequency of manic symptoms in fibromyalgia does influence the choice of treatment? |
title_full | The high frequency of manic symptoms in fibromyalgia does influence the choice of treatment? |
title_fullStr | The high frequency of manic symptoms in fibromyalgia does influence the choice of treatment? |
title_full_unstemmed | The high frequency of manic symptoms in fibromyalgia does influence the choice of treatment? |
title_short | The high frequency of manic symptoms in fibromyalgia does influence the choice of treatment? |
title_sort | high frequency of manic symptoms in fibromyalgia does influence the choice of treatment? |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779782/ https://www.ncbi.nlm.nih.gov/pubmed/17177985 http://dx.doi.org/10.1186/1745-0179-2-36 |
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