Up-regulation of HLA class-I antigen expression and antigen-specific CTL response in cervical cancer cells by the demethylating agent hydralazine and the histone deacetylase inhibitor valproic acid

BACKGROUND: DNA hypermethylation and histone deacetylation are epigenetic events that contribute to the absence or downregulated expression of different components of the tumor recognition complex. These events affect the processing and presentation of antigenic peptides to CTLs by HLA class-I molec...

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Detalles Bibliográficos
Autores principales: Mora-García, María de Lourdes, Duenas-González, Alfonso, Hernández-Montes, Jorge, De la Cruz-Hernández, Erick, Pérez-Cárdenas, Enrique, Weiss-Steider, Benny, Santiago-Osorio, Edelmiro, Ortíz-Navarrete, Vianney Francisco, Rosales, Víctor Hugo, Cantú, David, Lizano-Soberón, Marcela, Rojo-Aguilar, Martha Patricia, Monroy-García, Alberto
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781077/
https://www.ncbi.nlm.nih.gov/pubmed/17192185
http://dx.doi.org/10.1186/1479-5876-4-55

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