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Comparative Genomics of Large Mitochondria in Placozoans

The first sequenced mitochondrial genome of a placozoan, Trichoplax adhaerens, challenged the conventional wisdom that a compact mitochondrial genome is a common feature among all animals. Three additional placozoan mitochondrial genomes representing highly divergent clades have been sequenced to de...

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Detalles Bibliográficos
Autores principales: Signorovitch, Ana Y, Buss, Leo W, Dellaporta, Stephen L
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781491/
https://www.ncbi.nlm.nih.gov/pubmed/17222063
http://dx.doi.org/10.1371/journal.pgen.0030013
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author Signorovitch, Ana Y
Buss, Leo W
Dellaporta, Stephen L
author_facet Signorovitch, Ana Y
Buss, Leo W
Dellaporta, Stephen L
author_sort Signorovitch, Ana Y
collection PubMed
description The first sequenced mitochondrial genome of a placozoan, Trichoplax adhaerens, challenged the conventional wisdom that a compact mitochondrial genome is a common feature among all animals. Three additional placozoan mitochondrial genomes representing highly divergent clades have been sequenced to determine whether the large Trichoplax mtDNA is a shared feature among members of the phylum Placozoa or a uniquely derived condition. All three mitochondrial genomes were found to be very large, 32- to 37-kb, circular molecules, having the typical 12 respiratory chain genes, 24 tRNAs, rnS, and rnL. They share with the Trichoplax mitochondrial genome the absence of atp8, atp9, and all ribosomal protein genes, the presence of several cox1 introns, and a large open reading frame containing an intron group I LAGLIDADG endonuclease domain. The differences in mtDNA size within Placozoa are due to variation in intergenic spacer regions and the presence or absence of long open reading frames of unknown function. Phylogenetic analyses of the 12 respiratory chain genes support the monophyly of Placozoa. The similarities in composition and structure between the three mitochondrial genomes reported here and that of Trichoplax's mtDNA suggest that their uncompacted state is a shared ancestral feature to other nonmetazoans while their gene content is a derived feature shared only among the Metazoa.
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spelling pubmed-17814912007-01-25 Comparative Genomics of Large Mitochondria in Placozoans Signorovitch, Ana Y Buss, Leo W Dellaporta, Stephen L PLoS Genet Research Article The first sequenced mitochondrial genome of a placozoan, Trichoplax adhaerens, challenged the conventional wisdom that a compact mitochondrial genome is a common feature among all animals. Three additional placozoan mitochondrial genomes representing highly divergent clades have been sequenced to determine whether the large Trichoplax mtDNA is a shared feature among members of the phylum Placozoa or a uniquely derived condition. All three mitochondrial genomes were found to be very large, 32- to 37-kb, circular molecules, having the typical 12 respiratory chain genes, 24 tRNAs, rnS, and rnL. They share with the Trichoplax mitochondrial genome the absence of atp8, atp9, and all ribosomal protein genes, the presence of several cox1 introns, and a large open reading frame containing an intron group I LAGLIDADG endonuclease domain. The differences in mtDNA size within Placozoa are due to variation in intergenic spacer regions and the presence or absence of long open reading frames of unknown function. Phylogenetic analyses of the 12 respiratory chain genes support the monophyly of Placozoa. The similarities in composition and structure between the three mitochondrial genomes reported here and that of Trichoplax's mtDNA suggest that their uncompacted state is a shared ancestral feature to other nonmetazoans while their gene content is a derived feature shared only among the Metazoa. Public Library of Science 2007-01 2007-01-12 /pmc/articles/PMC1781491/ /pubmed/17222063 http://dx.doi.org/10.1371/journal.pgen.0030013 Text en © 2007 Signorovitch et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Signorovitch, Ana Y
Buss, Leo W
Dellaporta, Stephen L
Comparative Genomics of Large Mitochondria in Placozoans
title Comparative Genomics of Large Mitochondria in Placozoans
title_full Comparative Genomics of Large Mitochondria in Placozoans
title_fullStr Comparative Genomics of Large Mitochondria in Placozoans
title_full_unstemmed Comparative Genomics of Large Mitochondria in Placozoans
title_short Comparative Genomics of Large Mitochondria in Placozoans
title_sort comparative genomics of large mitochondria in placozoans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781491/
https://www.ncbi.nlm.nih.gov/pubmed/17222063
http://dx.doi.org/10.1371/journal.pgen.0030013
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