Polymorphisms of CUL5 Are Associated with CD4(+) T Cell Loss in HIV-1 Infected Individuals

Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (Apobec3) antiretroviral factors cause hypermutation of proviral DNA leading to degradation or replication-incompetent HIV-1. However, HIV-1 viral infectivity factor (Vif) suppresses Apobec3 activity through the Cullin 5-Elongi...

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Detalles Bibliográficos
Autores principales: An, Ping, Duggal, Priya, Wang, Li Hua, O'Brien, Stephen J, Donfield, Sharyne, Goedert, James J, Phair, John, Buchbinder, Susan, Kirk, Gregory D, Winkler, Cheryl A
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781497/
https://www.ncbi.nlm.nih.gov/pubmed/17257057
http://dx.doi.org/10.1371/journal.pgen.0030019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781497/
https://www.ncbi.nlm.nih.gov/pubmed/17257057
http://dx.doi.org/10.1371/journal.pgen.0030019

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