Cargando…

Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.

BACKGROUND: One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on the migration of eosinophils. Its serum content significantly correlates with the intensity of allergic symptoms, so it might be interesting to know whether vaccination has any influ...

Descripción completa

Detalles Bibliográficos
Autores principales: Jahnz-Rózyk, Karina, Brydak, Lidia B, Targowski, Tomasz, Machała, Magdalena, Plusa, Tadeusz
Formato: Texto
Lenguaje:English
Publicado: 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781554/
https://www.ncbi.nlm.nih.gov/pubmed/15223611
http://dx.doi.org/10.1080/09511920410001713501
_version_ 1782131900695969792
author Jahnz-Rózyk, Karina
Brydak, Lidia B
Targowski, Tomasz
Machała, Magdalena
Plusa, Tadeusz
author_facet Jahnz-Rózyk, Karina
Brydak, Lidia B
Targowski, Tomasz
Machała, Magdalena
Plusa, Tadeusz
author_sort Jahnz-Rózyk, Karina
collection PubMed
description BACKGROUND: One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on the migration of eosinophils. Its serum content significantly correlates with the intensity of allergic symptoms, so it might be interesting to know whether vaccination has any influence on serum expression of this chemokine. AIMS: Comparison of the humoral response to influenza vaccine and post-vaccination changes in the serum eotaxin level in patients with allergic bronchial asthma and healthy controls. METHODS: Forty-two asthmatics and 45 healthy individuals were vaccinated with a single dose of influenza subunit vaccine (Influvac). The serum eotaxin level and the antibody response to haemagglutinin (HI) and neuraminidase (NI) glycoproteins were measured before and after vaccination. RESULTS: A significant increase of geometric mean titres of HI and NI was observed in both groups. There were no significant differences between the groups in meanfold increase of HI and NI titres, response rate and protective level of HI. After vaccination, a significant decrease of the mean serum eotaxin value was observed in patients with asthma (149.4 +/- 71.0 versus 125.1 +/- 67.0, p= 0.0017), while no similar effect was present in healthy individuals (153.4 +/- 56.9 versus 159.3 +/- 54.4, p= 0.5). CONCLUSIONS: The results indicate that in patients with allergic bronchial asthma influenza vaccinations assure efficient protective antibody level and modulate the serum level of eotaxin.
format Text
id pubmed-1781554
institution National Center for Biotechnology Information
language English
publishDate 2004
record_format MEDLINE/PubMed
spelling pubmed-17815542007-01-25 Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma. Jahnz-Rózyk, Karina Brydak, Lidia B Targowski, Tomasz Machała, Magdalena Plusa, Tadeusz Mediators Inflamm Research Article BACKGROUND: One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on the migration of eosinophils. Its serum content significantly correlates with the intensity of allergic symptoms, so it might be interesting to know whether vaccination has any influence on serum expression of this chemokine. AIMS: Comparison of the humoral response to influenza vaccine and post-vaccination changes in the serum eotaxin level in patients with allergic bronchial asthma and healthy controls. METHODS: Forty-two asthmatics and 45 healthy individuals were vaccinated with a single dose of influenza subunit vaccine (Influvac). The serum eotaxin level and the antibody response to haemagglutinin (HI) and neuraminidase (NI) glycoproteins were measured before and after vaccination. RESULTS: A significant increase of geometric mean titres of HI and NI was observed in both groups. There were no significant differences between the groups in meanfold increase of HI and NI titres, response rate and protective level of HI. After vaccination, a significant decrease of the mean serum eotaxin value was observed in patients with asthma (149.4 +/- 71.0 versus 125.1 +/- 67.0, p= 0.0017), while no similar effect was present in healthy individuals (153.4 +/- 56.9 versus 159.3 +/- 54.4, p= 0.5). CONCLUSIONS: The results indicate that in patients with allergic bronchial asthma influenza vaccinations assure efficient protective antibody level and modulate the serum level of eotaxin. 2004-06 /pmc/articles/PMC1781554/ /pubmed/15223611 http://dx.doi.org/10.1080/09511920410001713501 Text en
spellingShingle Research Article
Jahnz-Rózyk, Karina
Brydak, Lidia B
Targowski, Tomasz
Machała, Magdalena
Plusa, Tadeusz
Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.
title Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.
title_full Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.
title_fullStr Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.
title_full_unstemmed Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.
title_short Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.
title_sort effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781554/
https://www.ncbi.nlm.nih.gov/pubmed/15223611
http://dx.doi.org/10.1080/09511920410001713501
work_keys_str_mv AT jahnzrozykkarina effectofinfluenzavaccinationsonimmuneresponseandserumeotaxinlevelinpatientswithallergicbronchialasthma
AT brydaklidiab effectofinfluenzavaccinationsonimmuneresponseandserumeotaxinlevelinpatientswithallergicbronchialasthma
AT targowskitomasz effectofinfluenzavaccinationsonimmuneresponseandserumeotaxinlevelinpatientswithallergicbronchialasthma
AT machałamagdalena effectofinfluenzavaccinationsonimmuneresponseandserumeotaxinlevelinpatientswithallergicbronchialasthma
AT plusatadeusz effectofinfluenzavaccinationsonimmuneresponseandserumeotaxinlevelinpatientswithallergicbronchialasthma