Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression.

Moderate-severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1alpha) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear p...

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Autores principales: Merendino, Rosaria Alba, Di Pasquale, Giuseppe, De Luca, Filippo, Di Pasquale, Laura, Ferlazzo, Edoardo, Martino, Gabriella, Palumbo, Maura Carmela, Morabito, Fortunato, Gangemi, Sebastiano
Formato: Texto
Lenguaje:English
Publicado: 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781561/
https://www.ncbi.nlm.nih.gov/pubmed/15223613
http://dx.doi.org/10.1080/09511920410001713484
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author Merendino, Rosaria Alba
Di Pasquale, Giuseppe
De Luca, Filippo
Di Pasquale, Laura
Ferlazzo, Edoardo
Martino, Gabriella
Palumbo, Maura Carmela
Morabito, Fortunato
Gangemi, Sebastiano
author_facet Merendino, Rosaria Alba
Di Pasquale, Giuseppe
De Luca, Filippo
Di Pasquale, Laura
Ferlazzo, Edoardo
Martino, Gabriella
Palumbo, Maura Carmela
Morabito, Fortunato
Gangemi, Sebastiano
author_sort Merendino, Rosaria Alba
collection PubMed
description Moderate-severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1alpha) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP-1alpha in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP-1alpha was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.
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spelling pubmed-17815612007-01-25 Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression. Merendino, Rosaria Alba Di Pasquale, Giuseppe De Luca, Filippo Di Pasquale, Laura Ferlazzo, Edoardo Martino, Gabriella Palumbo, Maura Carmela Morabito, Fortunato Gangemi, Sebastiano Mediators Inflamm Research Article Moderate-severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1alpha) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP-1alpha in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP-1alpha was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease. 2004-06 /pmc/articles/PMC1781561/ /pubmed/15223613 http://dx.doi.org/10.1080/09511920410001713484 Text en
spellingShingle Research Article
Merendino, Rosaria Alba
Di Pasquale, Giuseppe
De Luca, Filippo
Di Pasquale, Laura
Ferlazzo, Edoardo
Martino, Gabriella
Palumbo, Maura Carmela
Morabito, Fortunato
Gangemi, Sebastiano
Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression.
title Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression.
title_full Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression.
title_fullStr Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression.
title_full_unstemmed Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression.
title_short Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression.
title_sort involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781561/
https://www.ncbi.nlm.nih.gov/pubmed/15223613
http://dx.doi.org/10.1080/09511920410001713484
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