Interleukin-18 and CD30 serum levels in patients with moderate-severe depression.

Interleukin-18 (IL-18), a pro-inflammatory cytokine that plays an important role in the T-cell-helper type 1 response, is a new member of the family of cytokines produced in the brain. CD30 is a marker of T-cell-helper type 2 lymphocytes. We evaluated IL-18 and CD30 serum levels in 10 patients affec...

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Detalles Bibliográficos
Autores principales: Merendino, Rosaria Alba, Di Rosa, Antonio Enrico, Di Pasquale, Giuseppe, Minciullo, Paola Lucia, Mangraviti, Carmela, Costantino, Antonella, Ruello, Antonella, Gangemi, Sebastiano
Formato: Texto
Lenguaje:English
Publicado: 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781663/
https://www.ncbi.nlm.nih.gov/pubmed/12396479
http://dx.doi.org/10.1080/096293502900000131
Descripción
Sumario:Interleukin-18 (IL-18), a pro-inflammatory cytokine that plays an important role in the T-cell-helper type 1 response, is a new member of the family of cytokines produced in the brain. CD30 is a marker of T-cell-helper type 2 lymphocytes. We evaluated IL-18 and CD30 serum levels in 10 patients affected by moderate-severe depression (MSD). We demonstrated for the first time that serum IL-18 levels of MSD patients were significantly higher than those of healthy donors. On the contrary, no significant difference was found between serum CD30 levels of MSD patients compared with those of healthy donors. These data strengthen the hypothesis that MSD disease is associated with an inflammatory response, mainly T-cell-helper type 1, and suggest an important role for IL-18 in the pathophysiology of MSD.

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