Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis.

Basal, lipopolysaccharide (LPS) and silica-stimulated prostaglandin (PG) production were compared between peripheral blood mononuclear cells (PBMNC) from UC patients and healthy subjects (HS). Basal and LPS-stimulated PBMNC PGI2, but not PGE2, production was greater in UC. LPS stimulated both PGE2 a...

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Detalles Bibliográficos
Autores principales: Punchard, N A, Cason, J, Mullins, J, Chander, C, Thompson, R P
Formato: Texto
Lenguaje:English
Publicado: 2000
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781758/
https://www.ncbi.nlm.nih.gov/pubmed/11132777
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author Punchard, N A
Cason, J
Mullins, J
Chander, C
Thompson, R P
author_facet Punchard, N A
Cason, J
Mullins, J
Chander, C
Thompson, R P
author_sort Punchard, N A
collection PubMed
description Basal, lipopolysaccharide (LPS) and silica-stimulated prostaglandin (PG) production were compared between peripheral blood mononuclear cells (PBMNC) from UC patients and healthy subjects (HS). Basal and LPS-stimulated PBMNC PGI2, but not PGE2, production was greater in UC. LPS stimulated both PGE2 and PGI2 by PBMNC from HS and UC patients. Silica stimulated production of both PGs by cells from HS but only PGE2 by cells from UC patients. The differences in responses to silica and LPS may result from differences in activation of NFkappaB or, alternatively, prior sensitisation to one of these agents. That PBMNC PGE2 production is not increased in UC, as it is in Crohn's disease, suggests that there are differences in PBMNC behaviour between these two diseases.
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spelling pubmed-17817582007-01-25 Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis. Punchard, N A Cason, J Mullins, J Chander, C Thompson, R P Mediators Inflamm Research Article Basal, lipopolysaccharide (LPS) and silica-stimulated prostaglandin (PG) production were compared between peripheral blood mononuclear cells (PBMNC) from UC patients and healthy subjects (HS). Basal and LPS-stimulated PBMNC PGI2, but not PGE2, production was greater in UC. LPS stimulated both PGE2 and PGI2 by PBMNC from HS and UC patients. Silica stimulated production of both PGs by cells from HS but only PGE2 by cells from UC patients. The differences in responses to silica and LPS may result from differences in activation of NFkappaB or, alternatively, prior sensitisation to one of these agents. That PBMNC PGE2 production is not increased in UC, as it is in Crohn's disease, suggests that there are differences in PBMNC behaviour between these two diseases. 2000 /pmc/articles/PMC1781758/ /pubmed/11132777 Text en
spellingShingle Research Article
Punchard, N A
Cason, J
Mullins, J
Chander, C
Thompson, R P
Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis.
title Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis.
title_full Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis.
title_fullStr Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis.
title_full_unstemmed Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis.
title_short Lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis.
title_sort lipopolysaccharide and silica-stimulated mononuclear cell prostaglandin production in ulcerative colitis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781758/
https://www.ncbi.nlm.nih.gov/pubmed/11132777
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AT casonj lipopolysaccharideandsilicastimulatedmononuclearcellprostaglandinproductioninulcerativecolitis
AT mullinsj lipopolysaccharideandsilicastimulatedmononuclearcellprostaglandinproductioninulcerativecolitis
AT chanderc lipopolysaccharideandsilicastimulatedmononuclearcellprostaglandinproductioninulcerativecolitis
AT thompsonrp lipopolysaccharideandsilicastimulatedmononuclearcellprostaglandinproductioninulcerativecolitis

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