Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes.

A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative...

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Detalles Bibliográficos
Autores principales: Abiko, T, Nakatsubo, S
Formato: Texto
Lenguaje:English
Publicado: 2000
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781761/
https://www.ncbi.nlm.nih.gov/pubmed/11132780
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author Abiko, T
Nakatsubo, S
author_facet Abiko, T
Nakatsubo, S
author_sort Abiko, T
collection PubMed
description A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impaired T-lymphocyte transformation by PHA in uremic patients suffering from recurrent infectious diseases. The synthetic analogue was found to have stronger restorative activity than those of our synthetic TP II and [Phe (4F)3] TP II.
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spelling pubmed-17817612007-01-25 Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes. Abiko, T Nakatsubo, S Mediators Inflamm Research Article A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impaired T-lymphocyte transformation by PHA in uremic patients suffering from recurrent infectious diseases. The synthetic analogue was found to have stronger restorative activity than those of our synthetic TP II and [Phe (4F)3] TP II. 2000 /pmc/articles/PMC1781761/ /pubmed/11132780 Text en
spellingShingle Research Article
Abiko, T
Nakatsubo, S
Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes.
title Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes.
title_full Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes.
title_fullStr Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes.
title_full_unstemmed Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes.
title_short Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes.
title_sort synthesis of [i-nai3]] thymopoietin ii and examination of its immunological effect on the uremic t-lymphocytes.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781761/
https://www.ncbi.nlm.nih.gov/pubmed/11132780
work_keys_str_mv AT abikot synthesisofinai3thymopoietiniiandexaminationofitsimmunologicaleffectontheuremictlymphocytes
AT nakatsubos synthesisofinai3thymopoietiniiandexaminationofitsimmunologicaleffectontheuremictlymphocytes

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