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Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report.

Cystic fibrosis (CF) lung disease is characterized by persistent inflammation. Antiinflammatory drugs, such as corticosteroids and ibuprofen, have proved to slow the decline of pulmonary function although their use is limited because of frequent adverse events. We hypothesized that colchicine could...

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Detalles Bibliográficos
Autores principales: Sermet-Gaudelus, I, Stoven, V, Annereau, J P, Witko-Sarsat, V, Reinert, P, Guyot, M, Descamps-Latscha, B, Lallemand, J Y, Lenoir, G
Formato: Texto
Lenguaje:English
Publicado: 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781779/
https://www.ncbi.nlm.nih.gov/pubmed/10704084
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author Sermet-Gaudelus, I
Stoven, V
Annereau, J P
Witko-Sarsat, V
Reinert, P
Guyot, M
Descamps-Latscha, B
Lallemand, J Y
Lenoir, G
author_facet Sermet-Gaudelus, I
Stoven, V
Annereau, J P
Witko-Sarsat, V
Reinert, P
Guyot, M
Descamps-Latscha, B
Lallemand, J Y
Lenoir, G
author_sort Sermet-Gaudelus, I
collection PubMed
description Cystic fibrosis (CF) lung disease is characterized by persistent inflammation. Antiinflammatory drugs, such as corticosteroids and ibuprofen, have proved to slow the decline of pulmonary function although their use is limited because of frequent adverse events. We hypothesized that colchicine could be an alternative treatment because of its antiinflammatory properties and upregulatory effect on cystic fibrosis transmembrane regulator (CFTR) closely related proteins. We herein present results obtained in an open study of eight CF children treated with colchicine for at least 6 months. Clinical status was better in all patients and respiratory function tests significantly improved in five. Median duration of antibiotherapy decreased significantly. These preliminary results support our hypothesis of a beneficial effect of colchicine in CF patients and stress the need for a controlled therapeutic trial.
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spelling pubmed-17817792007-01-25 Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report. Sermet-Gaudelus, I Stoven, V Annereau, J P Witko-Sarsat, V Reinert, P Guyot, M Descamps-Latscha, B Lallemand, J Y Lenoir, G Mediators Inflamm Research Article Cystic fibrosis (CF) lung disease is characterized by persistent inflammation. Antiinflammatory drugs, such as corticosteroids and ibuprofen, have proved to slow the decline of pulmonary function although their use is limited because of frequent adverse events. We hypothesized that colchicine could be an alternative treatment because of its antiinflammatory properties and upregulatory effect on cystic fibrosis transmembrane regulator (CFTR) closely related proteins. We herein present results obtained in an open study of eight CF children treated with colchicine for at least 6 months. Clinical status was better in all patients and respiratory function tests significantly improved in five. Median duration of antibiotherapy decreased significantly. These preliminary results support our hypothesis of a beneficial effect of colchicine in CF patients and stress the need for a controlled therapeutic trial. 1999 /pmc/articles/PMC1781779/ /pubmed/10704084 Text en
spellingShingle Research Article
Sermet-Gaudelus, I
Stoven, V
Annereau, J P
Witko-Sarsat, V
Reinert, P
Guyot, M
Descamps-Latscha, B
Lallemand, J Y
Lenoir, G
Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report.
title Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report.
title_full Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report.
title_fullStr Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report.
title_full_unstemmed Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report.
title_short Interest of colchicine for the treatment of cystic fibrosis patients. Preliminary report.
title_sort interest of colchicine for the treatment of cystic fibrosis patients. preliminary report.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781779/
https://www.ncbi.nlm.nih.gov/pubmed/10704084
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