Estimation of SLE activity based on the serum level of chosen cytokines and superoxide radical generation.

We estimated the serum levels of IL-6, TNF-alpha and IL-10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of s...

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Detalles Bibliográficos
Autores principales: Waszczykowska, E, Robak, E, Wozniacka, A, Narbutt, J, Torzecka, J D, Sysa-Jedrzejowska, A
Formato: Texto
Lenguaje:English
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781789/
https://www.ncbi.nlm.nih.gov/pubmed/10704146
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author Waszczykowska, E
Robak, E
Wozniacka, A
Narbutt, J
Torzecka, J D
Sysa-Jedrzejowska, A
author_facet Waszczykowska, E
Robak, E
Wozniacka, A
Narbutt, J
Torzecka, J D
Sysa-Jedrzejowska, A
author_sort Waszczykowska, E
collection PubMed
description We estimated the serum levels of IL-6, TNF-alpha and IL-10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of superoxide anion generation by granulocytes, in correlation with SLE activity. These results indicate that oxygen metabolism and the examined cytokines play an important role in pathogenesis of SLE. The assessment of these parameters can be useful in the estimation of disease activity.
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spelling pubmed-17817892007-01-25 Estimation of SLE activity based on the serum level of chosen cytokines and superoxide radical generation. Waszczykowska, E Robak, E Wozniacka, A Narbutt, J Torzecka, J D Sysa-Jedrzejowska, A Mediators Inflamm Research Article We estimated the serum levels of IL-6, TNF-alpha and IL-10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of superoxide anion generation by granulocytes, in correlation with SLE activity. These results indicate that oxygen metabolism and the examined cytokines play an important role in pathogenesis of SLE. The assessment of these parameters can be useful in the estimation of disease activity. 1999 /pmc/articles/PMC1781789/ /pubmed/10704146 Text en
spellingShingle Research Article
Waszczykowska, E
Robak, E
Wozniacka, A
Narbutt, J
Torzecka, J D
Sysa-Jedrzejowska, A
Estimation of SLE activity based on the serum level of chosen cytokines and superoxide radical generation.
title Estimation of SLE activity based on the serum level of chosen cytokines and superoxide radical generation.
title_full Estimation of SLE activity based on the serum level of chosen cytokines and superoxide radical generation.
title_fullStr Estimation of SLE activity based on the serum level of chosen cytokines and superoxide radical generation.
title_full_unstemmed Estimation of SLE activity based on the serum level of chosen cytokines and superoxide radical generation.
title_short Estimation of SLE activity based on the serum level of chosen cytokines and superoxide radical generation.
title_sort estimation of sle activity based on the serum level of chosen cytokines and superoxide radical generation.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781789/
https://www.ncbi.nlm.nih.gov/pubmed/10704146
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AT wozniackaa estimationofsleactivitybasedontheserumlevelofchosencytokinesandsuperoxideradicalgeneration
AT narbuttj estimationofsleactivitybasedontheserumlevelofchosencytokinesandsuperoxideradicalgeneration
AT torzeckajd estimationofsleactivitybasedontheserumlevelofchosencytokinesandsuperoxideradicalgeneration
AT sysajedrzejowskaa estimationofsleactivitybasedontheserumlevelofchosencytokinesandsuperoxideradicalgeneration

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