Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets.

In a previous work we have shown that heparin, in the presence of ozone (O3), promotes a dose-dependent platelet aggregation, while after Ca2+ chelation with citrate, platelet aggregation is almost negligible. These results led us to think that aggregation may enhance the release of platelet compone...

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Detalles Bibliográficos
Autores principales: Valacchi, G, Bocci, V
Formato: Texto
Lenguaje:English
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781810/
https://www.ncbi.nlm.nih.gov/pubmed/10704074
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author Valacchi, G
Bocci, V
author_facet Valacchi, G
Bocci, V
author_sort Valacchi, G
collection PubMed
description In a previous work we have shown that heparin, in the presence of ozone (O3), promotes a dose-dependent platelet aggregation, while after Ca2+ chelation with citrate, platelet aggregation is almost negligible. These results led us to think that aggregation may enhance the release of platelet components. We have here shown that indeed significantly higher amount of platelet-derived growth factor (PDGF), transforming growth factor beta1 (TGF-beta1) and interleukin-8 (IL-8) are released in a dose-dependent manner after ozonation of heparinised platelet-rich plasma samples. These findings may explain the enhanced healing of torpid ulcers in patients with chronic limb ischemia treated with O3 autohaemoteraphy (O3-AHT).
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spelling pubmed-17818102007-01-25 Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets. Valacchi, G Bocci, V Mediators Inflamm Research Article In a previous work we have shown that heparin, in the presence of ozone (O3), promotes a dose-dependent platelet aggregation, while after Ca2+ chelation with citrate, platelet aggregation is almost negligible. These results led us to think that aggregation may enhance the release of platelet components. We have here shown that indeed significantly higher amount of platelet-derived growth factor (PDGF), transforming growth factor beta1 (TGF-beta1) and interleukin-8 (IL-8) are released in a dose-dependent manner after ozonation of heparinised platelet-rich plasma samples. These findings may explain the enhanced healing of torpid ulcers in patients with chronic limb ischemia treated with O3 autohaemoteraphy (O3-AHT). 1999 /pmc/articles/PMC1781810/ /pubmed/10704074 Text en
spellingShingle Research Article
Valacchi, G
Bocci, V
Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets.
title Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets.
title_full Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets.
title_fullStr Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets.
title_full_unstemmed Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets.
title_short Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets.
title_sort studies on the biological effects of ozone: 10. release of factors from ozonated human platelets.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781810/
https://www.ncbi.nlm.nih.gov/pubmed/10704074
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