Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.

On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E- and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1beta. Such ligands appear to be different from the ones present in promyel...

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Detalles Bibliográficos
Autores principales: Palma, C, Bellarosa, D, Nardelli, F, Mannori, G, Manzini, S
Formato: Texto
Lenguaje:English
Publicado: 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781838/
https://www.ncbi.nlm.nih.gov/pubmed/9705609
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author Palma, C
Bellarosa, D
Nardelli, F
Mannori, G
Manzini, S
author_facet Palma, C
Bellarosa, D
Nardelli, F
Mannori, G
Manzini, S
author_sort Palma, C
collection PubMed
description On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E- and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1beta. Such ligands appear to be different from the ones present in promyelocytic cells in order to promote cell adhesion to immobilized selectins. The expression of selectin-ligands on HUVEC cells suggest that selectins can participate in endothelial signalling besides their role as adhesion molecules for circulating blood cells. However, despite their role in chemotaxis, selectins do not contribute to HUVEC tube formation in Matrigel.
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spelling pubmed-17818382007-01-25 Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells. Palma, C Bellarosa, D Nardelli, F Mannori, G Manzini, S Mediators Inflamm Research Article On human endothelial cells from umbilical cord (HUVEC) are present, in addition to E- and P-selectins, their cognate ligands. Differently from selectins, the ligand expression is constitutive and not modulated by interleukin-1beta. Such ligands appear to be different from the ones present in promyelocytic cells in order to promote cell adhesion to immobilized selectins. The expression of selectin-ligands on HUVEC cells suggest that selectins can participate in endothelial signalling besides their role as adhesion molecules for circulating blood cells. However, despite their role in chemotaxis, selectins do not contribute to HUVEC tube formation in Matrigel. 1998 /pmc/articles/PMC1781838/ /pubmed/9705609 Text en
spellingShingle Research Article
Palma, C
Bellarosa, D
Nardelli, F
Mannori, G
Manzini, S
Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.
title Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.
title_full Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.
title_fullStr Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.
title_full_unstemmed Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.
title_short Constitutive expression of E- and P-selectin cognate ligands in human endothelial cells.
title_sort constitutive expression of e- and p-selectin cognate ligands in human endothelial cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781838/
https://www.ncbi.nlm.nih.gov/pubmed/9705609
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AT mannorig constitutiveexpressionofeandpselectincognateligandsinhumanendothelialcells
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