Azathioprine in inflammatory bowel disease, a safe alternative?

Azathioprine and its metabolite 6-mercaptopurine are effective in the treatment of inflammatory bowel disease. They are mostly used for reduction of the use of steroids, maintenance therapy after remission induction by cyclosporin and treatment of fistulae in Crohn's disease. Adverse effects oc...

Descripción completa

Detalles Bibliográficos
Autor principal: Tanis, A A
Formato: Texto
Lenguaje:English
Publicado: 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781843/
https://www.ncbi.nlm.nih.gov/pubmed/9705598
_version_ 1782131988422983680
author Tanis, A A
author_facet Tanis, A A
author_sort Tanis, A A
collection PubMed
description Azathioprine and its metabolite 6-mercaptopurine are effective in the treatment of inflammatory bowel disease. They are mostly used for reduction of the use of steroids, maintenance therapy after remission induction by cyclosporin and treatment of fistulae in Crohn's disease. Adverse effects occur in about 15% of patients. The main side effects are pancreatitis, allergic reactions, fever and bone marrow suppression. Symptoms, management and prevention are discussed. A blood monitoring schedule is suggested. Azathioprine and 6-mercaptopurine seem to be safe in pregnancy. There may be a slight increased risk for developing a non-Hodgkin's lymphoma.
format Text
id pubmed-1781843
institution National Center for Biotechnology Information
language English
publishDate 1998
record_format MEDLINE/PubMed
spelling pubmed-17818432007-01-25 Azathioprine in inflammatory bowel disease, a safe alternative? Tanis, A A Mediators Inflamm Research Article Azathioprine and its metabolite 6-mercaptopurine are effective in the treatment of inflammatory bowel disease. They are mostly used for reduction of the use of steroids, maintenance therapy after remission induction by cyclosporin and treatment of fistulae in Crohn's disease. Adverse effects occur in about 15% of patients. The main side effects are pancreatitis, allergic reactions, fever and bone marrow suppression. Symptoms, management and prevention are discussed. A blood monitoring schedule is suggested. Azathioprine and 6-mercaptopurine seem to be safe in pregnancy. There may be a slight increased risk for developing a non-Hodgkin's lymphoma. 1998 /pmc/articles/PMC1781843/ /pubmed/9705598 Text en
spellingShingle Research Article
Tanis, A A
Azathioprine in inflammatory bowel disease, a safe alternative?
title Azathioprine in inflammatory bowel disease, a safe alternative?
title_full Azathioprine in inflammatory bowel disease, a safe alternative?
title_fullStr Azathioprine in inflammatory bowel disease, a safe alternative?
title_full_unstemmed Azathioprine in inflammatory bowel disease, a safe alternative?
title_short Azathioprine in inflammatory bowel disease, a safe alternative?
title_sort azathioprine in inflammatory bowel disease, a safe alternative?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781843/
https://www.ncbi.nlm.nih.gov/pubmed/9705598
work_keys_str_mv AT tanisaa azathioprineininflammatoryboweldiseaseasafealternative

Ejemplares similares