IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.

The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine releas...

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Detalles Bibliográficos
Autores principales: Westin, U, Lundberg, E, Ohlsson, K
Formato: Texto
Lenguaje:English
Publicado: 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781850/
https://www.ncbi.nlm.nih.gov/pubmed/9705610
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author Westin, U
Lundberg, E
Ohlsson, K
author_facet Westin, U
Lundberg, E
Ohlsson, K
author_sort Westin, U
collection PubMed
description The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.
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spelling pubmed-17818502007-01-25 IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release. Westin, U Lundberg, E Ohlsson, K Mediators Inflamm Research Article The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release. 1998 /pmc/articles/PMC1781850/ /pubmed/9705610 Text en
spellingShingle Research Article
Westin, U
Lundberg, E
Ohlsson, K
IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.
title IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.
title_full IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.
title_fullStr IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.
title_full_unstemmed IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.
title_short IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.
title_sort ige-mediated histamine release from nasal mucosa is inhibited by slpi (secretory leukocyte protease inhibitor) to the level of spontaneous release.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781850/
https://www.ncbi.nlm.nih.gov/pubmed/9705610
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AT ohlssonk igemediatedhistaminereleasefromnasalmucosaisinhibitedbyslpisecretoryleukocyteproteaseinhibitortothelevelofspontaneousrelease

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