Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis

The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-γ in IL-12-deficient mice. Alth...

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Detalles Bibliográficos
Autores principales: Hultgren, Olof H, Stenson, Martin, Tarkowski, Andrzej
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17823/
https://www.ncbi.nlm.nih.gov/pubmed/11178125
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author Hultgren, Olof H
Stenson, Martin
Tarkowski, Andrzej
author_facet Hultgren, Olof H
Stenson, Martin
Tarkowski, Andrzej
author_sort Hultgren, Olof H
collection PubMed
description The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-γ in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals.
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spelling pubmed-178232001-03-08 Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis Hultgren, Olof H Stenson, Martin Tarkowski, Andrzej Arthritis Res Primary Research The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-γ in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals. BioMed Central 2001 2000-11-03 /pmc/articles/PMC17823/ /pubmed/11178125 Text en Copyright © 2000 BioMed Central Ltd on behalf of the copyright holders
spellingShingle Primary Research
Hultgren, Olof H
Stenson, Martin
Tarkowski, Andrzej
Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis
title Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis
title_full Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis
title_fullStr Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis
title_full_unstemmed Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis
title_short Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis
title_sort role of il-12 in staphylococcus aureus-triggered arthritis and sepsis
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17823/
https://www.ncbi.nlm.nih.gov/pubmed/11178125
work_keys_str_mv AT hultgrenolofh roleofil12instaphylococcusaureustriggeredarthritisandsepsis
AT stensonmartin roleofil12instaphylococcusaureustriggeredarthritisandsepsis
AT tarkowskiandrzej roleofil12instaphylococcusaureustriggeredarthritisandsepsis

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