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Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells
CD4(+) memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or IL-4 after a brief stimulation. RAPB Tm contained significantly more IFN-γ producers than normal cells. Many rheumatoid arthritis (...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2001
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17825/ https://www.ncbi.nlm.nih.gov/pubmed/11178127 |
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author | Davis, Laurie S Cush, John J Schulze-Koops, Hendrik Lipsky, Peter E |
author_facet | Davis, Laurie S Cush, John J Schulze-Koops, Hendrik Lipsky, Peter E |
author_sort | Davis, Laurie S |
collection | PubMed |
description | CD4(+) memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or IL-4 after a brief stimulation. RAPB Tm contained significantly more IFN-γ producers than normal cells. Many rheumatoid arthritis (RA) synovial Tm produced IFN-γ alone (40%) and fewer cells produced IL-2 or IL-4. An in vitro model was employed to generate polarized T-helper (Th) effectors. Normal and RAPB Tm differentiated into both IFN-γ- and IL-4-producing effectors. RA synovial fluid (RASF) Tm demonstrated defective responsiveness, exhibiting diminished differentiation of IL-4 effectors, whereas RA synovial tissue (RAST) Tm exhibited defective generation of IFN-γ and IL-4 producers. |
format | Text |
id | pubmed-17825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-178252001-03-08 Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells Davis, Laurie S Cush, John J Schulze-Koops, Hendrik Lipsky, Peter E Arthritis Res Primary Research CD4(+) memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or IL-4 after a brief stimulation. RAPB Tm contained significantly more IFN-γ producers than normal cells. Many rheumatoid arthritis (RA) synovial Tm produced IFN-γ alone (40%) and fewer cells produced IL-2 or IL-4. An in vitro model was employed to generate polarized T-helper (Th) effectors. Normal and RAPB Tm differentiated into both IFN-γ- and IL-4-producing effectors. RA synovial fluid (RASF) Tm demonstrated defective responsiveness, exhibiting diminished differentiation of IL-4 effectors, whereas RA synovial tissue (RAST) Tm exhibited defective generation of IFN-γ and IL-4 producers. BioMed Central 2001 2000-11-02 /pmc/articles/PMC17825/ /pubmed/11178127 Text en Copyright © 2000 BioMed Central Ltd on behalf of the copyright holders |
spellingShingle | Primary Research Davis, Laurie S Cush, John J Schulze-Koops, Hendrik Lipsky, Peter E Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells |
title | Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells |
title_full | Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells |
title_fullStr | Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells |
title_full_unstemmed | Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells |
title_short | Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells |
title_sort | rheumatoid synovial cd4(+) t cells exhibit a reduced capacity to differentiate into il-4-producing t-helper-2 effector cells |
topic | Primary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17825/ https://www.ncbi.nlm.nih.gov/pubmed/11178127 |
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