The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)

Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2...

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Detalles Bibliográficos
Autores principales: Kraan, Maarten C, Patel, Dhavalkumar D, Haringman, Jasper J, Smith, Malcolm D, Weedon, Helen, Ahern, Michael J, Breedveld, Ferdinand C, Tak, Paul P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17826/
https://www.ncbi.nlm.nih.gov/pubmed/11178128
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author Kraan, Maarten C
Patel, Dhavalkumar D
Haringman, Jasper J
Smith, Malcolm D
Weedon, Helen
Ahern, Michael J
Breedveld, Ferdinand C
Tak, Paul P
author_facet Kraan, Maarten C
Patel, Dhavalkumar D
Haringman, Jasper J
Smith, Malcolm D
Weedon, Helen
Ahern, Michael J
Breedveld, Ferdinand C
Tak, Paul P
author_sort Kraan, Maarten C
collection PubMed
description Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 protein levels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization.
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spelling pubmed-178262001-03-08 The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8) Kraan, Maarten C Patel, Dhavalkumar D Haringman, Jasper J Smith, Malcolm D Weedon, Helen Ahern, Michael J Breedveld, Ferdinand C Tak, Paul P Arthritis Res Primary Research Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 protein levels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization. BioMed Central 2001 2000-11-09 /pmc/articles/PMC17826/ /pubmed/11178128 Text en Copyright © 2000 BioMed Central Ltd on behalf of the copyright holders
spellingShingle Primary Research
Kraan, Maarten C
Patel, Dhavalkumar D
Haringman, Jasper J
Smith, Malcolm D
Weedon, Helen
Ahern, Michael J
Breedveld, Ferdinand C
Tak, Paul P
The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)
title The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)
title_full The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)
title_fullStr The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)
title_full_unstemmed The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)
title_short The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)
title_sort development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine cxcl8 (interleukin-8)
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17826/
https://www.ncbi.nlm.nih.gov/pubmed/11178128
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