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Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB

BACKGROUND: Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons. APOB exists as two natural isoforms: the full-length APOB100 isoform, assembled into LDL, VLDL, IDL and Lp(a) and...

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Detalles Bibliográficos
Autores principales:	Khoo, Bernard, Roca, Xavier, Chew, Shern L, Krainer, Adrian R
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784105/ https://www.ncbi.nlm.nih.gov/pubmed/17233885 http://dx.doi.org/10.1186/1471-2199-8-3

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