Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized

BACKGROUND: Human mammary epithelial cells (HMEC) overcome two well-characterized genetic and epigenetic barriers as they progress from primary cells to fully immortalized cell lines in vitro. Finite lifespan HMEC overcome an Rb-mediated stress-associated senescence barrier (stasis), and a stringent...

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Detalles Bibliográficos
Autores principales: Li, Yizheng, Pan, Jing, Li, Jian-Liang, Lee, Jee Hyung, Tunkey, Chris, Saraf, Katie, Garbe, James C, Whitley, Maryann Z, Jelinsky, Scott A, Stampfer, Martha R, Haney, Steven A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784108/
https://www.ncbi.nlm.nih.gov/pubmed/17233903
http://dx.doi.org/10.1186/1476-4598-6-7

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