The Inhibitory Effect of Clindamycin on Lactobacillus in vitro

Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp. Methods: Concentrations of clindamycin ranging from 1.95–20 000 mg/ml were studied for their effect on the growth of six strains of Lactobacillus . Results: Clindamycin concentrations between 1....

Descripción completa

Detalles Bibliográficos
Autores principales: Aroutcheva, Alla, Simoes, Jose A., Shott, Susan, Faro, Sebastian
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784659/
https://www.ncbi.nlm.nih.gov/pubmed/11916182
http://dx.doi.org/10.1155/S1064744901000394
Descripción
Sumario:Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp. Methods: Concentrations of clindamycin ranging from 1.95–20 000 mg/ml were studied for their effect on the growth of six strains of Lactobacillus . Results: Clindamycin concentrations between 1.95–31.25 mg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 mg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1000 mg/ml. Conclusion: High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus .

Ejemplares similares