The Inhibitory Effect of Clindamycin on Lactobacillus in vitro

Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp. Methods: Concentrations of clindamycin ranging from 1.95–20 000 mg/ml were studied for their effect on the growth of six strains of Lactobacillus . Results: Clindamycin concentrations between 1....

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Detalles Bibliográficos
Autores principales: Aroutcheva, Alla, Simoes, Jose A., Shott, Susan, Faro, Sebastian
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784659/
https://www.ncbi.nlm.nih.gov/pubmed/11916182
http://dx.doi.org/10.1155/S1064744901000394
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author Aroutcheva, Alla
Simoes, Jose A.
Shott, Susan
Faro, Sebastian
author_facet Aroutcheva, Alla
Simoes, Jose A.
Shott, Susan
Faro, Sebastian
author_sort Aroutcheva, Alla
collection PubMed
description Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp. Methods: Concentrations of clindamycin ranging from 1.95–20 000 mg/ml were studied for their effect on the growth of six strains of Lactobacillus . Results: Clindamycin concentrations between 1.95–31.25 mg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 mg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1000 mg/ml. Conclusion: High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus .
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spelling pubmed-17846592007-02-05 The Inhibitory Effect of Clindamycin on Lactobacillus in vitro Aroutcheva, Alla Simoes, Jose A. Shott, Susan Faro, Sebastian Infect Dis Obstet Gynecol Research Article Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp. Methods: Concentrations of clindamycin ranging from 1.95–20 000 mg/ml were studied for their effect on the growth of six strains of Lactobacillus . Results: Clindamycin concentrations between 1.95–31.25 mg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 mg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1000 mg/ml. Conclusion: High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus . Hindawi Publishing Corporation 2001 /pmc/articles/PMC1784659/ /pubmed/11916182 http://dx.doi.org/10.1155/S1064744901000394 Text en Copyright © 2001 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aroutcheva, Alla
Simoes, Jose A.
Shott, Susan
Faro, Sebastian
The Inhibitory Effect of Clindamycin on Lactobacillus in vitro
title The Inhibitory Effect of Clindamycin on Lactobacillus in vitro
title_full The Inhibitory Effect of Clindamycin on Lactobacillus in vitro
title_fullStr The Inhibitory Effect of Clindamycin on Lactobacillus in vitro
title_full_unstemmed The Inhibitory Effect of Clindamycin on Lactobacillus in vitro
title_short The Inhibitory Effect of Clindamycin on Lactobacillus in vitro
title_sort inhibitory effect of clindamycin on lactobacillus in vitro
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784659/
https://www.ncbi.nlm.nih.gov/pubmed/11916182
http://dx.doi.org/10.1155/S1064744901000394
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