Cargando…

Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis

Objective: To evaluate amniotic fluid glucose, matrix metalloproteinase (MMP)-9, interleukin (IL)-6, and IL-12 for diagnosing subclinical chorioamnionitis in women with preterm labor. Methods: Forty-four women in preterm labor at 22–35 weeks gestation with suspected subclinical chorioamnionitis unde...

Descripción completa

Detalles Bibliográficos
Autores principales: Edwards, Rodney K., Clark, Penny, Locksmith, Gregory J., Duff, Patrick
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784661/
https://www.ncbi.nlm.nih.gov/pubmed/11916177
http://dx.doi.org/10.1155/S1064744901000345
_version_ 1782132073917579264
author Edwards, Rodney K.
Clark, Penny
Locksmith, Gregory J.
Duff, Patrick
author_facet Edwards, Rodney K.
Clark, Penny
Locksmith, Gregory J.
Duff, Patrick
author_sort Edwards, Rodney K.
collection PubMed
description Objective: To evaluate amniotic fluid glucose, matrix metalloproteinase (MMP)-9, interleukin (IL)-6, and IL-12 for diagnosing subclinical chorioamnionitis in women with preterm labor. Methods: Forty-four women in preterm labor at 22–35 weeks gestation with suspected subclinical chorioamnionitis underwentamniocentesis.Amniotic fluid analysis included Gram stain, culture, and determination of glucose, MMP-9, IL-6, and IL-12 concentrations. Median values of these analytes were compared using the Mann-Whitney U test. Sensitivity, specificity, and positive and negative predictive values were calculated for tests using a positive amniotic fluid culture or delivery within 24 hours as the key outcome variables Results: Amniotic fluid concentrations of glucose, MMP-9, and IL-6 correlated closely with positive culture or delivery within 24 hours. IL-12 concentrations did not correlate with either a positive culture or delivery within 24 hours. Conclusions: Amniotic fluid glucose, MMP-9, and IL-6 reliably predict microbial invasion of the amniotic cavity or imminent delivery. IL-12 values did not correlate with amniotic fluid culture results or imminent delivery.
format Text
id pubmed-1784661
institution National Center for Biotechnology Information
language English
publishDate 2001
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-17846612007-02-05 Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis Edwards, Rodney K. Clark, Penny Locksmith, Gregory J. Duff, Patrick Infect Dis Obstet Gynecol Research Article Objective: To evaluate amniotic fluid glucose, matrix metalloproteinase (MMP)-9, interleukin (IL)-6, and IL-12 for diagnosing subclinical chorioamnionitis in women with preterm labor. Methods: Forty-four women in preterm labor at 22–35 weeks gestation with suspected subclinical chorioamnionitis underwentamniocentesis.Amniotic fluid analysis included Gram stain, culture, and determination of glucose, MMP-9, IL-6, and IL-12 concentrations. Median values of these analytes were compared using the Mann-Whitney U test. Sensitivity, specificity, and positive and negative predictive values were calculated for tests using a positive amniotic fluid culture or delivery within 24 hours as the key outcome variables Results: Amniotic fluid concentrations of glucose, MMP-9, and IL-6 correlated closely with positive culture or delivery within 24 hours. IL-12 concentrations did not correlate with either a positive culture or delivery within 24 hours. Conclusions: Amniotic fluid glucose, MMP-9, and IL-6 reliably predict microbial invasion of the amniotic cavity or imminent delivery. IL-12 values did not correlate with amniotic fluid culture results or imminent delivery. Hindawi Publishing Corporation 2001 /pmc/articles/PMC1784661/ /pubmed/11916177 http://dx.doi.org/10.1155/S1064744901000345 Text en Copyright © 2001 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Edwards, Rodney K.
Clark, Penny
Locksmith, Gregory J.
Duff, Patrick
Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis
title Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis
title_full Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis
title_fullStr Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis
title_full_unstemmed Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis
title_short Performance Characteristics of Putative Tests for Subclinical Chorioamnionitis
title_sort performance characteristics of putative tests for subclinical chorioamnionitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784661/
https://www.ncbi.nlm.nih.gov/pubmed/11916177
http://dx.doi.org/10.1155/S1064744901000345
work_keys_str_mv AT edwardsrodneyk performancecharacteristicsofputativetestsforsubclinicalchorioamnionitis
AT clarkpenny performancecharacteristicsofputativetestsforsubclinicalchorioamnionitis
AT locksmithgregoryj performancecharacteristicsofputativetestsforsubclinicalchorioamnionitis
AT duffpatrick performancecharacteristicsofputativetestsforsubclinicalchorioamnionitis