New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts

By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncodi...

Descripción completa

Detalles Bibliográficos
Autores principales: Pagano, Aldo, Castelnuovo, Manuele, Tortelli, Federico, Ferrari, Roberto, Dieci, Giorgio, Cancedda, Ranieri
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790723/
https://www.ncbi.nlm.nih.gov/pubmed/17274687
http://dx.doi.org/10.1371/journal.pgen.0030001
_version_ 1782132128465551360
author Pagano, Aldo
Castelnuovo, Manuele
Tortelli, Federico
Ferrari, Roberto
Dieci, Giorgio
Cancedda, Ranieri
author_facet Pagano, Aldo
Castelnuovo, Manuele
Tortelli, Federico
Ferrari, Roberto
Dieci, Giorgio
Cancedda, Ranieri
author_sort Pagano, Aldo
collection PubMed
description By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart.
format Text
id pubmed-1790723
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-17907232007-02-02 New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts Pagano, Aldo Castelnuovo, Manuele Tortelli, Federico Ferrari, Roberto Dieci, Giorgio Cancedda, Ranieri PLoS Genet Research Article By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart. Public Library of Science 2007-02 2007-02-02 /pmc/articles/PMC1790723/ /pubmed/17274687 http://dx.doi.org/10.1371/journal.pgen.0030001 Text en © 2007 Pagano et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Pagano, Aldo
Castelnuovo, Manuele
Tortelli, Federico
Ferrari, Roberto
Dieci, Giorgio
Cancedda, Ranieri
New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts
title New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts
title_full New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts
title_fullStr New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts
title_full_unstemmed New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts
title_short New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts
title_sort new small nuclear rna gene-like transcriptional units as sources of regulatory transcripts
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790723/
https://www.ncbi.nlm.nih.gov/pubmed/17274687
http://dx.doi.org/10.1371/journal.pgen.0030001
work_keys_str_mv AT paganoaldo newsmallnuclearrnageneliketranscriptionalunitsassourcesofregulatorytranscripts
AT castelnuovomanuele newsmallnuclearrnageneliketranscriptionalunitsassourcesofregulatorytranscripts
AT tortellifederico newsmallnuclearrnageneliketranscriptionalunitsassourcesofregulatorytranscripts
AT ferrariroberto newsmallnuclearrnageneliketranscriptionalunitsassourcesofregulatorytranscripts
AT diecigiorgio newsmallnuclearrnageneliketranscriptionalunitsassourcesofregulatorytranscripts
AT canceddaranieri newsmallnuclearrnageneliketranscriptionalunitsassourcesofregulatorytranscripts

Ejemplares similares