Pressure-Tuning Raman Spectra of Diiodine Thioamide Compounds: Models for Antithyroid Drug Activity

The pressure-tuning Raman spectra of five solid, diiodine heterocyclic thioamide compounds (mbztS)I(2) (mbztS = N-methyl-2-mercaptobenzothiazole) (1); [(mbztS)(2)I](+)[I(7)](−) (2); (pySH)I(2) (pySH = 2-mercaptopyridine) (3); [(pySH)(pyS](+)[I(3)](−) (4); (thpm)(I(2))(2) or possibly [(thpm)I(2)](+)[I(3)](−) (thpm = 2-mercapto-3,4,5,6-tertahydropyrimidine (5) have been measured for pressures up to ∼ 50 kbar using a diamond-anvil cell. Compounds 1, 4, and 5 undergo pressure-induced phase transitions at ∼ 35, ∼ 25, and ∼ 32 kbar, respectively. Following the phase transition in 1, the pressure dependences of the vibrational modes, which were originally located at 84, 111, and 161 cm(−1) and are associated with the S(⋯)I–I linkage, are 2.08, 1.78, and 0.57 cm(−1)/kbar, respectively. These pressure dependences are typical of low-energy vibrations. The pressure-tuning FT-Raman results for the pairs of compounds 1 , 2, 3, and 4 are remarkably similar to each other suggesting that the compounds are most probably perturbed diiodide compounds rather than ionic ones. The Raman data for 5 show that it is best formulated as (thpm)(I(2))(2) rather than [(thpm)(2)I](+)[I(3)](−).