Cargando…

Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations

AIMS/HYPOTHESIS: Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic properties. Several reports suggest that genetic variants in the adiponectin gene are associated with circulating levels of adiponectin, insulin sensitivity and type 2 diabetes risk. Recently two receptors for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Collins, S. C., Luan, J., Thompson, A. J., Daly, A., Semple, R. K., O’Rahilly, S., Wareham, N. J., Barroso, I.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2007
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794135/ https://www.ncbi.nlm.nih.gov/pubmed/17216283 http://dx.doi.org/10.1007/s00125-006-0534-7

Ejemplares similares

Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals
por: Finucane, F. M., et al.
Publicado: (2009)

Evaluating the Role of LPIN1 Variation in Insulin Resistance, Body Weight, and Human Lipodystrophy in U.K. Populations
por: Fawcett, Katherine A., et al.
Publicado: (2008)

Loss of NPC1 function in a patient with a co-inherited novel insulin receptor mutation does not grossly modify the severity of the associated insulin resistance
por: Kirk, J., et al.
Publicado: (2010)

The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion
por: Rocha, Nuno, et al.
Publicado: (2017)

Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action
por: Barroso, Inês, et al.
Publicado: (2003)

Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling
por: Raffan, E., et al.
Publicado: (2011)

Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance
por: Agostini, Maura, et al.
Publicado: (2006)

In PLoS Biology, volume 1, issue 1:: Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action
por: Barroso, Inês, et al.
Publicado: (2003)

AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles
por: Jensen, Jørgen, et al.
Publicado: (2017)

Identification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2: C48R: A Novel Mutation in AGPAT2
por: Ramanathan, N., et al.
Publicado: (2012)

“Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture
por: O’Rahilly, Stephen
Publicado: (2021)

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations
por: Huang-Doran, Isabel, et al.
Publicado: (2016)

Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia
por: Minic, Marina, et al.
Publicado: (2017)

Insulin Receptor and the Kidney: Nephrocalcinosis in Patients with Recessive INSR Mutations
por: Simpkin, Arabella, et al.
Publicado: (2014)

Anatomía de Gardner
por: O'Rahilly, Ronan
Publicado: (1989)

Analysis of TBC1D4 in patients with severe insulin resistance
por: Dash, S., et al.
Publicado: (2010)

KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation
por: Pearce, Laura R., et al.
Publicado: (2013)

Loss of function mutations in the melanocortin 4 receptor in a UK birth cohort
por: Wade, Kaitlin H, et al.
Publicado: (2021)

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC
por: Rubio-Cabezas, Oscar, et al.
Publicado: (2009)

Adiponectin is associated with cardio-metabolic traits in Mexican children
por: He, Juehua, et al.
Publicado: (2019)

Ovarian Hyperandrogenism and Response to Gonadotropin-releasing Hormone Analogues in Primary Severe Insulin Resistance
por: Huang-Doran, Isabel, et al.
Publicado: (2021)

The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals
por: Vimaleswaran, Karani Santhanakrishnan, et al.
Publicado: (2008)

Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions
por: O'Rahilly, Stephen, et al.
Publicado: (2008)

Fat: an evolving issue
por: Speakman, John R., et al.
Publicado: (2012)

When Two Pandemics Meet: Why Is Obesity Associated with Increased COVID-19 Mortality?
por: Lockhart, Sam M., et al.
Publicado: (2020)

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes
por: Eiden, Michael, et al.
Publicado: (2015)

A multicomponent screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes
por: Chalmers, J., et al.
Publicado: (2020)

Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes
por: Huang-Doran, Isabel, et al.
Publicado: (2011)

Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms
por: Sim, M. F. Michelle, et al.
Publicado: (2013)

Association of Adiponectin Gene Polymorphism with Adiponectin Levels And Risk for Insulin Resistance Syndrome
por: Prakash, Jai, et al.
Publicado: (2015)

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation
por: Payne, Victoria A., et al.
Publicado: (2008)

GDF15: A Hormone Conveying Somatic Distress to the Brain
por: Lockhart, Samuel M, et al.
Publicado: (2020)

Genetic Architecture of Plasma Adiponectin Overlaps With the Genetics of Metabolic Syndrome–Related Traits
por: Henneman, Peter, et al.
Publicado: (2010)

Human Frame Shift Mutations Affecting the Carboxyl Terminus of Perilipin Increase Lipolysis by Failing to Sequester the Adipose Triglyceride Lipase (ATGL) Coactivator AB-hydrolase-containing 5 (ABHD5)
por: Gandotra, Sheetal, et al.
Publicado: (2011)

Adiponectin signaling and function in insulin target tissues
por: Ruan, Hong, et al.
Publicado: (2016)

Interaction of Adiponectin Genotypes and Insulin Resistance on the Occurrence of Taiwanese Metabolic Syndrome
por: Chen, Chun-Chieh, et al.
Publicado: (2021)

Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis
por: Lowe, C E, et al.
Publicado: (2012)

The Hormonal Control of Food Intake
por: Coll, Anthony P., et al.
Publicado: (2007)

An Appreciation of Robert Turner
por: O'Rahilly, Stephen, et al.
Publicado: (2008)

A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome
por: Peters, Kirsten E, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_nuatcq3mrl4druk2b59vmlgck4