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Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography
Cancer therapy has shown terrific progress leading to important reduction of morbidity and mortality of several kinds of cancer. The therapeutic management of oncologic patients includes combinations of drugs, radiation therapy and surgery. Many of these therapies produce adverse cardiovascular comp...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794233/ https://www.ncbi.nlm.nih.gov/pubmed/17254324 http://dx.doi.org/10.1186/1476-7120-5-4 |
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author | Galderisi, Maurizio Marra, Francesco Esposito, Roberta Lomoriello, Vincenzo Schiano Pardo, Moira de Divitiis, Oreste |
author_facet | Galderisi, Maurizio Marra, Francesco Esposito, Roberta Lomoriello, Vincenzo Schiano Pardo, Moira de Divitiis, Oreste |
author_sort | Galderisi, Maurizio |
collection | PubMed |
description | Cancer therapy has shown terrific progress leading to important reduction of morbidity and mortality of several kinds of cancer. The therapeutic management of oncologic patients includes combinations of drugs, radiation therapy and surgery. Many of these therapies produce adverse cardiovascular complications which may negatively affect both the quality of life and the prognosis. For several years the most common noninvasive method of monitoring cardiotoxicity has been represented by radionuclide ventriculography while other tests as effort EKG and stress myocardial perfusion imaging may detect ischemic complications, and 24-hour Holter monitoring unmask suspected arrhythmias. Also biomarkers such as troponine I and T and B-type natriuretic peptide may be useful for early detection of cardiotoxicity. Today, the widely used non-invasive method of monitoring cardiotoxicity of cancer therapy is, however, represented by Doppler-echocardiography which allows to identify the main forms of cardiac complications of cancer therapy: left ventricular (systolic and diastolic) dysfunction, valve heart disease, pericarditis and pericardial effusion, carotid artery lesions. Advanced ultrasound tools, as Integrated Backscatter and Tissue Doppler, but also simple ultrasound detection of "lung comet" on the anterior and lateral chest can be helpful for early, subclinical diagnosis of cardiac involvement. Serial Doppler echocardiographic evaluation has to be encouraged in the oncologic patients, before, during and even late after therapy completion. This is crucial when using anthracyclines, which have early but, most importantly, late, cumulative cardiac toxicity. The echocardiographic monitoring appears even indispensable after radiation therapy, whose detrimental effects may appear several years after the end of irradiation. |
format | Text |
id | pubmed-1794233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-17942332007-02-07 Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography Galderisi, Maurizio Marra, Francesco Esposito, Roberta Lomoriello, Vincenzo Schiano Pardo, Moira de Divitiis, Oreste Cardiovasc Ultrasound Review Cancer therapy has shown terrific progress leading to important reduction of morbidity and mortality of several kinds of cancer. The therapeutic management of oncologic patients includes combinations of drugs, radiation therapy and surgery. Many of these therapies produce adverse cardiovascular complications which may negatively affect both the quality of life and the prognosis. For several years the most common noninvasive method of monitoring cardiotoxicity has been represented by radionuclide ventriculography while other tests as effort EKG and stress myocardial perfusion imaging may detect ischemic complications, and 24-hour Holter monitoring unmask suspected arrhythmias. Also biomarkers such as troponine I and T and B-type natriuretic peptide may be useful for early detection of cardiotoxicity. Today, the widely used non-invasive method of monitoring cardiotoxicity of cancer therapy is, however, represented by Doppler-echocardiography which allows to identify the main forms of cardiac complications of cancer therapy: left ventricular (systolic and diastolic) dysfunction, valve heart disease, pericarditis and pericardial effusion, carotid artery lesions. Advanced ultrasound tools, as Integrated Backscatter and Tissue Doppler, but also simple ultrasound detection of "lung comet" on the anterior and lateral chest can be helpful for early, subclinical diagnosis of cardiac involvement. Serial Doppler echocardiographic evaluation has to be encouraged in the oncologic patients, before, during and even late after therapy completion. This is crucial when using anthracyclines, which have early but, most importantly, late, cumulative cardiac toxicity. The echocardiographic monitoring appears even indispensable after radiation therapy, whose detrimental effects may appear several years after the end of irradiation. BioMed Central 2007-01-25 /pmc/articles/PMC1794233/ /pubmed/17254324 http://dx.doi.org/10.1186/1476-7120-5-4 Text en Copyright © 2007 Galderisi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Galderisi, Maurizio Marra, Francesco Esposito, Roberta Lomoriello, Vincenzo Schiano Pardo, Moira de Divitiis, Oreste Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography |
title | Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography |
title_full | Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography |
title_fullStr | Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography |
title_full_unstemmed | Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography |
title_short | Cancer therapy and cardiotoxicity: The need of serial Doppler echocardiography |
title_sort | cancer therapy and cardiotoxicity: the need of serial doppler echocardiography |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794233/ https://www.ncbi.nlm.nih.gov/pubmed/17254324 http://dx.doi.org/10.1186/1476-7120-5-4 |
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