Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2

BACKGROUND: PC cell-derived growth factor (PCDGF), also called epithelin/granulin precursor (GEP), is an 88-kDa secreted glycoprotein with the ability to stimulate cell proliferation in an autocrine fashion. In addition, some studies indicated that PCDGF participated in invasion, metastasis and surv...

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Detalles Bibliográficos
Autores principales: Liu, Yulan, Xi, Ling, Liao, Guoning, Wang, Wei, Tian, Xun, Wang, Beibei, Chen, Gang, Han, Zhiqiang, Wu, Mingfu, Wang, Shixuan, Zhou, Jianfeng, Xu, Gang, Lu, Yunping, Ma, Ding
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794415/
https://www.ncbi.nlm.nih.gov/pubmed/17261172
http://dx.doi.org/10.1186/1471-2407-7-22

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