CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference). Here we describe the first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler. C...

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Detalles Bibliográficos
Autores principales: Carpenter, Anne E, Jones, Thouis R, Lamprecht, Michael R, Clarke, Colin, Kang, In Han, Friman, Ola, Guertin, David A, Chang, Joo Han, Lindquist, Robert A, Moffat, Jason, Golland, Polina, Sabatini, David M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794559/
https://www.ncbi.nlm.nih.gov/pubmed/17076895
http://dx.doi.org/10.1186/gb-2006-7-10-r100
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author Carpenter, Anne E
Jones, Thouis R
Lamprecht, Michael R
Clarke, Colin
Kang, In Han
Friman, Ola
Guertin, David A
Chang, Joo Han
Lindquist, Robert A
Moffat, Jason
Golland, Polina
Sabatini, David M
author_facet Carpenter, Anne E
Jones, Thouis R
Lamprecht, Michael R
Clarke, Colin
Kang, In Han
Friman, Ola
Guertin, David A
Chang, Joo Han
Lindquist, Robert A
Moffat, Jason
Golland, Polina
Sabatini, David M
author_sort Carpenter, Anne E
collection PubMed
description Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference). Here we describe the first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler. CellProfiler can address a variety of biological questions quantitatively, including standard assays (for example, cell count, size, per-cell protein levels) and complex morphological assays (for example, cell/organelle shape or subcellular patterns of DNA or protein staining).
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spelling pubmed-17945592007-02-08 CellProfiler: image analysis software for identifying and quantifying cell phenotypes Carpenter, Anne E Jones, Thouis R Lamprecht, Michael R Clarke, Colin Kang, In Han Friman, Ola Guertin, David A Chang, Joo Han Lindquist, Robert A Moffat, Jason Golland, Polina Sabatini, David M Genome Biol Software Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference). Here we describe the first free, open-source system designed for flexible, high-throughput cell image analysis, CellProfiler. CellProfiler can address a variety of biological questions quantitatively, including standard assays (for example, cell count, size, per-cell protein levels) and complex morphological assays (for example, cell/organelle shape or subcellular patterns of DNA or protein staining). BioMed Central 2006 2006-10-31 /pmc/articles/PMC1794559/ /pubmed/17076895 http://dx.doi.org/10.1186/gb-2006-7-10-r100 Text en Copyright © 2006 Carpenter et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software
Carpenter, Anne E
Jones, Thouis R
Lamprecht, Michael R
Clarke, Colin
Kang, In Han
Friman, Ola
Guertin, David A
Chang, Joo Han
Lindquist, Robert A
Moffat, Jason
Golland, Polina
Sabatini, David M
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
title CellProfiler: image analysis software for identifying and quantifying cell phenotypes
title_full CellProfiler: image analysis software for identifying and quantifying cell phenotypes
title_fullStr CellProfiler: image analysis software for identifying and quantifying cell phenotypes
title_full_unstemmed CellProfiler: image analysis software for identifying and quantifying cell phenotypes
title_short CellProfiler: image analysis software for identifying and quantifying cell phenotypes
title_sort cellprofiler: image analysis software for identifying and quantifying cell phenotypes
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794559/
https://www.ncbi.nlm.nih.gov/pubmed/17076895
http://dx.doi.org/10.1186/gb-2006-7-10-r100
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