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Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins

BACKGROUND: Gene duplications have been hypothesized to be a major factor in enabling the evolution of tissue differentiation. Analyses of the expression profiles of duplicate genes in mammalian tissues have indicated that, with time, the expression patterns of duplicate genes diverge and become mor...

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Autores principales: Freilich, Shiri, Massingham, Tim, Blanc, Eric, Goldovsky, Leon, Thornton, Janet M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794571/
https://www.ncbi.nlm.nih.gov/pubmed/17029626
http://dx.doi.org/10.1186/gb-2006-7-10-r89
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author Freilich, Shiri
Massingham, Tim
Blanc, Eric
Goldovsky, Leon
Thornton, Janet M
author_facet Freilich, Shiri
Massingham, Tim
Blanc, Eric
Goldovsky, Leon
Thornton, Janet M
author_sort Freilich, Shiri
collection PubMed
description BACKGROUND: Gene duplications have been hypothesized to be a major factor in enabling the evolution of tissue differentiation. Analyses of the expression profiles of duplicate genes in mammalian tissues have indicated that, with time, the expression patterns of duplicate genes diverge and become more tissue specific. We explored the relationship between duplication events, the time at which they took place, and both the expression breadth of the duplicated genes and the cumulative expression breadth of the gene family to which they belong. RESULTS: We show that only duplicates that arose through post-multicellularity duplication events show a tendency to become more specifically expressed, whereas such a tendency is not observed for duplicates that arose in a unicellular ancestor. Unlike the narrow expression profile of the duplicated genes, the overall expression of gene families tends to maintain a global expression pattern. CONCLUSION: The work presented here supports the view suggested by the subfunctionalization model, namely that expression divergence in different tissues, following gene duplication, promotes the retention of a gene in the genome of multicellular species. The global expression profile of the gene families suggests division of expression between family members, whose expression becomes specialized. Because specialization of expression is coupled with an increased rate of sequence divergence, it can facilitate the evolution of new, tissue-specific functions.
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spelling pubmed-17945712007-02-08 Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins Freilich, Shiri Massingham, Tim Blanc, Eric Goldovsky, Leon Thornton, Janet M Genome Biol Research BACKGROUND: Gene duplications have been hypothesized to be a major factor in enabling the evolution of tissue differentiation. Analyses of the expression profiles of duplicate genes in mammalian tissues have indicated that, with time, the expression patterns of duplicate genes diverge and become more tissue specific. We explored the relationship between duplication events, the time at which they took place, and both the expression breadth of the duplicated genes and the cumulative expression breadth of the gene family to which they belong. RESULTS: We show that only duplicates that arose through post-multicellularity duplication events show a tendency to become more specifically expressed, whereas such a tendency is not observed for duplicates that arose in a unicellular ancestor. Unlike the narrow expression profile of the duplicated genes, the overall expression of gene families tends to maintain a global expression pattern. CONCLUSION: The work presented here supports the view suggested by the subfunctionalization model, namely that expression divergence in different tissues, following gene duplication, promotes the retention of a gene in the genome of multicellular species. The global expression profile of the gene families suggests division of expression between family members, whose expression becomes specialized. Because specialization of expression is coupled with an increased rate of sequence divergence, it can facilitate the evolution of new, tissue-specific functions. BioMed Central 2006 2006-10-09 /pmc/articles/PMC1794571/ /pubmed/17029626 http://dx.doi.org/10.1186/gb-2006-7-10-r89 Text en Copyright © 2006 Freilich et al.; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Freilich, Shiri
Massingham, Tim
Blanc, Eric
Goldovsky, Leon
Thornton, Janet M
Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
title Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
title_full Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
title_fullStr Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
title_full_unstemmed Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
title_short Relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
title_sort relating tissue specialization to the differentiation of expression of singleton and duplicate mouse proteins
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794571/
https://www.ncbi.nlm.nih.gov/pubmed/17029626
http://dx.doi.org/10.1186/gb-2006-7-10-r89
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