B-RAF and N-RAS Mutations Are Preserved during Short Time In Vitro Propagation and Differentially Impact Prognosis

In melanoma, the RAS/RAF/MEK/ERK signalling pathway is an area of great interest, because it regulates tumor cell proliferation and survival. A varying mutation rate has been reported for B-RAF and N-RAS, which has been largely attributed to the differential source of tumor DNA analyzed, e.g., fixed...

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Detalles Bibliográficos
Autores principales: Ugurel, Selma, Thirumaran, Ranjit K., Bloethner, Sandra, Gast, Andreas, Sucker, Antje, Mueller-Berghaus, Jan, Rittgen, Werner, Hemminki, Kari, Becker, Jürgen C., Kumar, Rajiv, Schadendorf, Dirk
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794595/
https://www.ncbi.nlm.nih.gov/pubmed/17311103
http://dx.doi.org/10.1371/journal.pone.0000236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794595/
https://www.ncbi.nlm.nih.gov/pubmed/17311103
http://dx.doi.org/10.1371/journal.pone.0000236

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