Newly Synthesized APOBEC3G Is Incorporated into HIV Virions, Inhibited by HIV RNA, and Subsequently Activated by RNase H

APOBEC3G (A3G) is a potent antiretroviral deoxycytidine deaminase that, when incorporated into HIV virions, hypermutates nascent viral DNA formed during reverse transcription. HIV Vif counters the effect of A3G by depleting intracellular stores of the enzyme, thereby blocking its virion incorporatio...

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Detalles Bibliográficos
Autores principales: Soros, Vanessa B, Yonemoto, Wes, Greene, Warner C
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796622/
https://www.ncbi.nlm.nih.gov/pubmed/17291161
http://dx.doi.org/10.1371/journal.ppat.0030015

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