Cargando…
Immunostimulation and Immunoinhibition of Premalignant Lesions
BACKGROUND: The immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells. HYPOTHESIS: A tumor-stimulatory immune response may be essential for survival of a neoplasm in vivo and for the biological progression from a pr...
Autor principal: | |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797005/ https://www.ncbi.nlm.nih.gov/pubmed/17280618 http://dx.doi.org/10.1186/1742-4682-4-6 |
_version_ | 1782132279098736640 |
---|---|
author | Prehn, Richmond T |
author_facet | Prehn, Richmond T |
author_sort | Prehn, Richmond T |
collection | PubMed |
description | BACKGROUND: The immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells. HYPOTHESIS: A tumor-stimulatory immune response may be essential for survival of a neoplasm in vivo and for the biological progression from a premalignant lesion to a malignancy. Neither a positive nor a negative correlation between the magnitude of an immune-cell infiltrate and a cancer's prognosis can reveal whether the infiltrate was stimulating or inhibiting to the tumor's growth unless the position on the nonlinear curve that relates tumor growth to the magnitude of the immune reaction is known. DISCUSSION: This hypothesis is discussed in relation to the development of human malignant melanomas and colorectal cancers. |
format | Text |
id | pubmed-1797005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-17970052007-02-13 Immunostimulation and Immunoinhibition of Premalignant Lesions Prehn, Richmond T Theor Biol Med Model Review BACKGROUND: The immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells. HYPOTHESIS: A tumor-stimulatory immune response may be essential for survival of a neoplasm in vivo and for the biological progression from a premalignant lesion to a malignancy. Neither a positive nor a negative correlation between the magnitude of an immune-cell infiltrate and a cancer's prognosis can reveal whether the infiltrate was stimulating or inhibiting to the tumor's growth unless the position on the nonlinear curve that relates tumor growth to the magnitude of the immune reaction is known. DISCUSSION: This hypothesis is discussed in relation to the development of human malignant melanomas and colorectal cancers. BioMed Central 2007-02-06 /pmc/articles/PMC1797005/ /pubmed/17280618 http://dx.doi.org/10.1186/1742-4682-4-6 Text en Copyright © 2007 Prehn; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Prehn, Richmond T Immunostimulation and Immunoinhibition of Premalignant Lesions |
title | Immunostimulation and Immunoinhibition of Premalignant Lesions |
title_full | Immunostimulation and Immunoinhibition of Premalignant Lesions |
title_fullStr | Immunostimulation and Immunoinhibition of Premalignant Lesions |
title_full_unstemmed | Immunostimulation and Immunoinhibition of Premalignant Lesions |
title_short | Immunostimulation and Immunoinhibition of Premalignant Lesions |
title_sort | immunostimulation and immunoinhibition of premalignant lesions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797005/ https://www.ncbi.nlm.nih.gov/pubmed/17280618 http://dx.doi.org/10.1186/1742-4682-4-6 |
work_keys_str_mv | AT prehnrichmondt immunostimulationandimmunoinhibitionofpremalignantlesions |