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Characterization of antibodies in single-chain format against the E7 oncoprotein of the Human papillomavirus type 16 and their improvement by mutagenesis

BACKGROUND: Human papillomaviruses (HPV) are the etiological agents of cervical cancer. The viral E7 protein plays a crucial role in viral oncogenesis. Many strategies have been explored to block the E7 oncoprotein activity. The single-chain variable antibody fragments (scFvs) are valuable tools in...

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Detalles Bibliográficos
Autores principales:	Donà, Maria Gabriella, Giorgi, Colomba, Accardi, Luisa
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797048/ https://www.ncbi.nlm.nih.gov/pubmed/17266749 http://dx.doi.org/10.1186/1471-2407-7-25

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