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Factors Affecting Trypanosome Maturation in Tsetse Flies

Trypanosoma brucei brucei infections which establish successfully in the tsetse fly midgut may subsequently mature into mammalian infective trypanosomes in the salivary glands. This maturation is not automatic and the control of these events is complex. Utilising direct in vivo feeding experiments,...

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Detalles Bibliográficos
Autores principales: Macleod, Ewan Thomas, Darby, Alistair Charles, Maudlin, Ian, Welburn, Sue Christina
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797825/
https://www.ncbi.nlm.nih.gov/pubmed/17318257
http://dx.doi.org/10.1371/journal.pone.0000239
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author Macleod, Ewan Thomas
Darby, Alistair Charles
Maudlin, Ian
Welburn, Sue Christina
author_facet Macleod, Ewan Thomas
Darby, Alistair Charles
Maudlin, Ian
Welburn, Sue Christina
author_sort Macleod, Ewan Thomas
collection PubMed
description Trypanosoma brucei brucei infections which establish successfully in the tsetse fly midgut may subsequently mature into mammalian infective trypanosomes in the salivary glands. This maturation is not automatic and the control of these events is complex. Utilising direct in vivo feeding experiments, we report maturation of T. b. brucei infections in tsetse is regulated by antioxidants as well as environmental stimuli. Dissection of the maturation process provides opportunities to develop transmission blocking vaccines for trypanosomiasis. The present work suggests L-cysteine and/or nitric oxide are necessary for the differentiation of trypanosome midgut infections in tsetse.
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spelling pubmed-17978252007-02-22 Factors Affecting Trypanosome Maturation in Tsetse Flies Macleod, Ewan Thomas Darby, Alistair Charles Maudlin, Ian Welburn, Sue Christina PLoS One Research Article Trypanosoma brucei brucei infections which establish successfully in the tsetse fly midgut may subsequently mature into mammalian infective trypanosomes in the salivary glands. This maturation is not automatic and the control of these events is complex. Utilising direct in vivo feeding experiments, we report maturation of T. b. brucei infections in tsetse is regulated by antioxidants as well as environmental stimuli. Dissection of the maturation process provides opportunities to develop transmission blocking vaccines for trypanosomiasis. The present work suggests L-cysteine and/or nitric oxide are necessary for the differentiation of trypanosome midgut infections in tsetse. Public Library of Science 2007-02-21 /pmc/articles/PMC1797825/ /pubmed/17318257 http://dx.doi.org/10.1371/journal.pone.0000239 Text en MacLeod et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Macleod, Ewan Thomas
Darby, Alistair Charles
Maudlin, Ian
Welburn, Sue Christina
Factors Affecting Trypanosome Maturation in Tsetse Flies
title Factors Affecting Trypanosome Maturation in Tsetse Flies
title_full Factors Affecting Trypanosome Maturation in Tsetse Flies
title_fullStr Factors Affecting Trypanosome Maturation in Tsetse Flies
title_full_unstemmed Factors Affecting Trypanosome Maturation in Tsetse Flies
title_short Factors Affecting Trypanosome Maturation in Tsetse Flies
title_sort factors affecting trypanosome maturation in tsetse flies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797825/
https://www.ncbi.nlm.nih.gov/pubmed/17318257
http://dx.doi.org/10.1371/journal.pone.0000239
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