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Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates
Hairpin polyamide–chlorambucil conjugates containing an α-diaminobutyric acid (α-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized γ-DABA turn. Although the DNA-binding properties of unconjugated polyamides are similar, the α-DABA conjugates display inc...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802559/ https://www.ncbi.nlm.nih.gov/pubmed/17170006 http://dx.doi.org/10.1093/nar/gkl1025 |