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LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
Transcriptional co-activator LEDGF/p75 is the major cellular interactor of HIV-1 integrase (IN), critical to efficient viral replication. In this work, a series of INs from the Betaretrovirus, Gammaretrovirus, Deltaretrovirus, Spumavirus and Lentivirus retroviral genera were tested for interaction w...
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| Formato: | Texto |
| Lenguaje: | English |
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Oxford University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802576/ https://www.ncbi.nlm.nih.gov/pubmed/17158150 http://dx.doi.org/10.1093/nar/gkl885 |