Cargando…

Improved nuclear localization of DNA-binding polyamides

Regulation of endogenous genes by DNA-binding polyamides requires effective nuclear localization. Previous work employing confocal microscopy to study uptake of fluorophore-labeled polyamides has demonstrated the difficulty of predicting a priori the nuclear uptake of a given polyamide. The data sug...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nickols, Nicholas G., Jacobs, Claire S., Farkas, Michelle E., Dervan, Peter B.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802595/ https://www.ncbi.nlm.nih.gov/pubmed/17175539 http://dx.doi.org/10.1093/nar/gkl1042

Ejemplares similares

Binding of hairpin pyrrole and imidazole polyamides to DNA: relationship between torsion angle and association rate constants
por: Han, Yong-Woon, et al.
Publicado: (2012)

Sequence-specific DNA cleavage mediated by bipyridine polyamide conjugates
por: Simon, Philippe, et al.
Publicado: (2008)

Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide
por: Diaz-Perez, Silvia, et al.
Publicado: (2018)

Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide
por: Kurmis, Alexis A, et al.
Publicado: (2019)

Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding
por: Chenoweth, David M., et al.
Publicado: (2010)

Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability
por: Viñas-Castells, Rosa, et al.
Publicado: (2014)

Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain
por: Tsutsui, Kimiko M., et al.
Publicado: (2011)

Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)
por: Knudsen, Nina Østergaard, et al.
Publicado: (2007)

Helicase binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilis
por: Ioannou, Charikleia, et al.
Publicado: (2006)

Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme
por: Taylor, Melissa J., et al.
Publicado: (2008)

Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice
por: Synold, Timothy W., et al.
Publicado: (2012)

Animal Toxicity of Hairpin Pyrrole-Imidazole Polyamides Varies with the Turn Unit
por: Yang, Fei, et al.
Publicado: (2013)

Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA
por: Chiarella, Sara, et al.
Publicado: (2013)

Proteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules
por: Ng, Siew Kit, et al.
Publicado: (2013)

ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains
por: Deigendesch, Nikolaus, et al.
Publicado: (2006)

Cooperative DNA binding by proteins through DNA shape complementarity
por: Hancock, Stephen P, et al.
Publicado: (2019)

Development of a single-stranded DNA-binding protein fluorescent fusion toolbox
por: Dubiel, Katarzyna, et al.
Publicado: (2020)

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering
por: van der Linden, Eddy, et al.
Publicado: (2009)

Multiple cytosolic DNA sensors bind plasmid DNA after transfection
por: Semenova, Nina, et al.
Publicado: (2019)

Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene
por: Ivanova, Olga, et al.
Publicado: (2007)

DNA linking number change induced by sequence-specific DNA-binding proteins
por: Chen, Bo, et al.
Publicado: (2010)

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites
por: Marchand, Christophe, et al.
Publicado: (2006)

Location analysis for the estrogen receptor-α reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements
por: Mason, Christopher E., et al.
Publicado: (2010)

Enhancing the cellular uptake of Py–Im polyamides through next-generation aryl turns
por: Meier, Jordan L., et al.
Publicado: (2012)

In vitro selection and characterization of cellulose-binding DNA aptamers
por: Boese, Benjamin J., et al.
Publicado: (2007)

The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function
por: Cattaruzzi, Giacomo, et al.
Publicado: (2007)

Systematic prediction of control proteins and their DNA binding sites
por: Sorokin, Valeriy, et al.
Publicado: (2009)

Multiple-binding-site mechanism explains concentration-dependent unbinding rates of DNA-binding proteins
por: Sing, Charles E., et al.
Publicado: (2014)

The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1
por: Ting, Nicholas S. Y., et al.
Publicado: (2009)

Dissecting the role of the ϕ29 terminal protein DNA binding residues in viral DNA replication
por: Holguera, Isabel, et al.
Publicado: (2015)

Genetic recombination in Bacillus subtilis: a division of labor between two single-strand DNA-binding proteins
por: Yadav, Tribhuwan, et al.
Publicado: (2012)

Arabidopsis thaliana telomeric DNA-binding protein 1 is required for telomere length homeostasis and its Myb-extension domain stabilizes plant telomeric DNA binding
por: Hwang, Moo Gak, et al.
Publicado: (2007)

Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates
por: Tsai, Sherry M., et al.
Publicado: (2007)

Elucidating the evolutionary conserved DNA-binding specificities of WRKY transcription factors by molecular dynamics and in vitro binding assays
por: Brand, Luise H., et al.
Publicado: (2013)

Telomeric localization of the modified DNA base J in the genome of the protozoan parasite Leishmania
por: Genest, Paul-André, et al.
Publicado: (2007)

A single molecule analysis of H-NS uncouples DNA binding affinity from DNA specificity
por: Gulvady, Ranjit, et al.
Publicado: (2018)

DNA microstructure influences selective binding of small molecules designed to target mixed-site DNA sequences
por: Laughlin-Toth, Sarah, et al.
Publicado: (2017)

DNA flowerstructure co-localizes with human pathogens in infected macrophages
por: Franch, Oskar, et al.
Publicado: (2020)

Rational design of an estrogen receptor mutant with altered DNA-binding specificity
por: Nguyen, Denis, et al.
Publicado: (2007)

What drives the binding of minor groove-directed ligands to DNA hairpins?
por: Lah, Jurij, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_illkpn2un59bqsulmkq1s41lu4