More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature

Highly accurate knockdown functional analyses based on RNA interference (RNAi) require the possible most complete hydrolysis of the targeted mRNA while avoiding the degradation of untargeted genes (off-target effects). This in turn requires significant improvements to target selection for two reason...

Descripción completa

Detalles Bibliográficos
Autor principal: Ladunga, Istvan
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802606/
https://www.ncbi.nlm.nih.gov/pubmed/17169992
http://dx.doi.org/10.1093/nar/gkl1065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802606/
https://www.ncbi.nlm.nih.gov/pubmed/17169992
http://dx.doi.org/10.1093/nar/gkl1065

Ejemplares similares