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More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature
Highly accurate knockdown functional analyses based on RNA interference (RNAi) require the possible most complete hydrolysis of the targeted mRNA while avoiding the degradation of untargeted genes (off-target effects). This in turn requires significant improvements to target selection for two reason...
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| Formato: | Texto |
| Lenguaje: | English |
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Oxford University Press
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802606/ https://www.ncbi.nlm.nih.gov/pubmed/17169992 http://dx.doi.org/10.1093/nar/gkl1065 |