Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models

BACKGROUND: Toll-like receptor (TLR)3 ligands serve as natural inducers of pro-inflammatory cytokines capable of promoting Type-1 adaptive immunity, and TLR3 is abundantly expressed by cells within the central nervous system (CNS). To improve the efficacy of vaccine strategies directed against CNS t...

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Detalles Bibliográficos
Autores principales: Zhu, Xinmei, Nishimura, Fumihiko, Sasaki, Kotaro, Fujita, Mitsugu, Dusak, Jill E, Eguchi, Junichi, Fellows-Mayle, Wendy, Storkus, Walter J, Walker, Paul R, Salazar, Andres M, Okada, Hideho
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802742/
https://www.ncbi.nlm.nih.gov/pubmed/17295916
http://dx.doi.org/10.1186/1479-5876-5-10

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