Elevated Rates of Sister Chromatid Exchange at Chromosome Ends

Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched...

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Detalles Bibliográficos
Autores principales: Rudd, M. Katharine, Friedman, Cynthia, Parghi, Sean S, Linardopoulou, Elena V, Hsu, Li, Trask, Barbara J
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802831/
https://www.ncbi.nlm.nih.gov/pubmed/17319749
http://dx.doi.org/10.1371/journal.pgen.0030032
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author Rudd, M. Katharine
Friedman, Cynthia
Parghi, Sean S
Linardopoulou, Elena V
Hsu, Li
Trask, Barbara J
author_facet Rudd, M. Katharine
Friedman, Cynthia
Parghi, Sean S
Linardopoulou, Elena V
Hsu, Li
Trask, Barbara J
author_sort Rudd, M. Katharine
collection PubMed
description Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome.
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spelling pubmed-18028312007-02-22 Elevated Rates of Sister Chromatid Exchange at Chromosome Ends Rudd, M. Katharine Friedman, Cynthia Parghi, Sean S Linardopoulou, Elena V Hsu, Li Trask, Barbara J PLoS Genet Research Article Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome. Public Library of Science 2007-02 2007-02-23 /pmc/articles/PMC1802831/ /pubmed/17319749 http://dx.doi.org/10.1371/journal.pgen.0030032 Text en © 2007 Rudd et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Rudd, M. Katharine
Friedman, Cynthia
Parghi, Sean S
Linardopoulou, Elena V
Hsu, Li
Trask, Barbara J
Elevated Rates of Sister Chromatid Exchange at Chromosome Ends
title Elevated Rates of Sister Chromatid Exchange at Chromosome Ends
title_full Elevated Rates of Sister Chromatid Exchange at Chromosome Ends
title_fullStr Elevated Rates of Sister Chromatid Exchange at Chromosome Ends
title_full_unstemmed Elevated Rates of Sister Chromatid Exchange at Chromosome Ends
title_short Elevated Rates of Sister Chromatid Exchange at Chromosome Ends
title_sort elevated rates of sister chromatid exchange at chromosome ends
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802831/
https://www.ncbi.nlm.nih.gov/pubmed/17319749
http://dx.doi.org/10.1371/journal.pgen.0030032
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