Cargando…

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism

BACKGROUND: Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides. Aβ is released from ectodomain cleaved amyloid precursor protein (APP) via intramembranous proteolysis by γ-secretase, a complex consisting of presenilin and a few other proteins. p23/TMP21,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vetrivel, Kulandaivelu S, Gong, Ping, Bowen, James W, Cheng, Haipeng, Chen, Ying, Carter, Meghan, Nguyen, Phuong D, Placanica, Lisa, Wieland, Felix T, Li, Yue-Ming, Kounnas, Maria Z, Thinakaran, Gopal
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803014/ https://www.ncbi.nlm.nih.gov/pubmed/17288597 http://dx.doi.org/10.1186/1750-1326-2-4

Ejemplares similares

Pathological and physiological functions of presenilins
por: Vetrivel, Kulandaivelu S, et al.
Publicado: (2006)

Alterations in Gene Expression in Mutant Amyloid Precursor Protein Transgenic Mice Lacking Niemann-Pick Type C1 Protein
por: Maulik, Mahua, et al.
Publicado: (2013)

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage
por: Pardossi-Piquard, Raphaëlle, et al.
Publicado: (2009)

Stringently regulated p23 expression is critical for coordinated movement in mice: implications for Alzheimer’s disease
por: Gong, Ping, et al.
Publicado: (2012)

Rat Chondrocyte-Associated Antigen Identified as Sialylated Transmembrane Protein Tmp21 Belonging to the p24 Protein Family
por: Osiecka-Iwan, Anna, et al.
Publicado: (2013)

Structural and Dynamic Study of the Transmembrane Domain of the Amyloid Precursor Protein
por: Nadezhdin, K.D., et al.
Publicado: (2011)

Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
por: Gong, Ping, et al.
Publicado: (2011)

Cholesterol twists the transmembrane Di-Gly region of amyloid-precursor protein
por: Wang, David Tzu-Wei, et al.
Publicado: (2023)

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants
por: Gorman, Paul M, et al.
Publicado: (2008)

Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains
por: Deatherage, Catherine L., et al.
Publicado: (2017)

TMP- SSurface2: A Novel Deep Learning-Based Surface Accessibility Predictor for Transmembrane Protein Sequence
por: Liu, Zhe, et al.
Publicado: (2021)

Structural Heterogeneity in Transmembrane Amyloid Precursor Protein Homodimer Is a Consequence of Environmental Selection
por: Dominguez, Laura, et al.
Publicado: (2014)

Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein
por: Clemente, Nicolina, et al.
Publicado: (2018)

Structural Characterization of the Amyloid Precursor Protein Transmembrane Domain and Its γ-Cleavage Site
por: Itkin, Anna, et al.
Publicado: (2017)

Masking the transmembrane region of the amyloid β precursor protein as a safe means to lower amyloid β production
por: Khan, Ayesha, et al.
Publicado: (2023)

TmpL, a Transmembrane Protein Required for Intracellular Redox Homeostasis and Virulence in a Plant and an Animal Fungal Pathogen
por: Kim, Kwang-Hyung, et al.
Publicado: (2009)

γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production
por: Takami, Mako, et al.
Publicado: (2012)

Impact of Bilayer Lipid Composition on the Structure and Topology of the Transmembrane Amyloid Precursor C99 Protein
por: Song, Yuanli, et al.
Publicado: (2014)

The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10
por: Hitschler, Lisa, et al.
Publicado: (2022)

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
por: Pandey, Poomy, et al.
Publicado: (2016)

Transcriptional Regulation of TMP21 by NFAT
por: Liu, Shengchun, et al.
Publicado: (2011)

The amyloid precursor protein: beyond amyloid
por: Zheng, Hui, et al.
Publicado: (2006)

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
por: Yan, Yan, et al.
Publicado: (2017)

Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain
por: Castro, Manuel A., et al.
Publicado: (2022)

Formation of extramembrane β-strands controls dimerization of transmembrane helices in amyloid precursor protein C99
por: Pantelopulos, George A., et al.
Publicado: (2022)

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase
por: Buggia-Prévot, Virginie, et al.
Publicado: (2014)

p23/Tmp21 Differentially Targets the Rac-GAP β2-Chimaerin and Protein Kinase C via Their C1 Domains
por: Wang, HongBin, et al.
Publicado: (2010)

Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs
por: Sato, Naoyuki, et al.
Publicado: (2012)

Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase
por: Lemmin, Thomas, et al.
Publicado: (2014)

Correction: Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs
por: Sato, Naoyuki, et al.
Publicado: (2012)

Involvement of the Transmembrane Protein p23 in Biosynthetic Protein Transport
por: Rojo, Manuel, et al.
Publicado: (1997)

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
por: Anandatheerthavarada, Hindupur K., et al.
Publicado: (2003)

Membrane topology of gp41 and amyloid precursor protein: Interfering transmembrane interactions as potential targets for HIV and Alzheimer treatment
por: Abad, Concepción, et al.
Publicado: (2009)

Regulation of global gene expression in brain by TMP21
por: Zhang, Xiaojie, et al.
Publicado: (2019)

Interactions between amyloid, amyloid precursor protein, and mitochondria
por: Wilkins, Heather M.
Publicado: (2023)

Biology and pathophysiology of the amyloid precursor protein
por: Zheng, Hui, et al.
Publicado: (2011)

Amyloid Precursor Protein and Alzheimer’s Disease
por: Orobets, Kseniia S., et al.
Publicado: (2023)

Amyloid precursor protein and its interacting proteins in neurodevelopment
por: Chau, Dennis Dik-Long, et al.
Publicado: (2023)

Amyloid-like Fibrils from an α-Helical Transmembrane Protein
por: Stroobants, Karen, et al.
Publicado: (2017)

Association of the transmembrane TGF-alpha precursor with a protein kinase complex
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_jo9j6ok03dvlaj64ia8anbvtq4