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Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism

BACKGROUND: Alzheimer's disease (AD) is characterized by cerebral deposition of β-amyloid (Aβ) peptides. Aβ is released from ectodomain cleaved amyloid precursor protein (APP) via intramembranous proteolysis by γ-secretase, a complex consisting of presenilin and a few other proteins. p23/TMP21,...

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Detalles Bibliográficos
Autores principales:	Vetrivel, Kulandaivelu S, Gong, Ping, Bowen, James W, Cheng, Haipeng, Chen, Ying, Carter, Meghan, Nguyen, Phuong D, Placanica, Lisa, Wieland, Felix T, Li, Yue-Ming, Kounnas, Maria Z, Thinakaran, Gopal
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803014/ https://www.ncbi.nlm.nih.gov/pubmed/17288597 http://dx.doi.org/10.1186/1750-1326-2-4

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