Role for Non-Proteolytic Control of M-phase Promoting Factor Activity at M-phase Exit

M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis. Thus, control of MPF activity via inhibitory phosphorylation is...

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Detalles Bibliográficos
Autores principales: D'Angiolella, Vincenzo, Palazzo, Luca, Santarpia, Concetta, Costanzo, Vincenzo, Grieco, Domenico
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803016/
https://www.ncbi.nlm.nih.gov/pubmed/17327911
http://dx.doi.org/10.1371/journal.pone.0000247

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