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A case-control study of GST polymorphisms and arsenic related skin lesions

BACKGROUND: Polymorphisms in GSTT1, GSTM1 and GSTP1 impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic biotransformation may influence disease susceptibility. GST activity is involve...

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Autores principales: McCarty, Kathleen M, Ryan, Louise, Houseman, E Andres, Williams, Paige L, Miller, David P, Quamruzzaman, Quazi, Rahman, Mahmuder, Mahiuddin, Golam, Smith, Thomas, Gonzalez, Ernesto, Su, Li, Christiani, David C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805433/
https://www.ncbi.nlm.nih.gov/pubmed/17284320
http://dx.doi.org/10.1186/1476-069X-6-5
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author McCarty, Kathleen M
Ryan, Louise
Houseman, E Andres
Williams, Paige L
Miller, David P
Quamruzzaman, Quazi
Rahman, Mahmuder
Mahiuddin, Golam
Smith, Thomas
Gonzalez, Ernesto
Su, Li
Christiani, David C
author_facet McCarty, Kathleen M
Ryan, Louise
Houseman, E Andres
Williams, Paige L
Miller, David P
Quamruzzaman, Quazi
Rahman, Mahmuder
Mahiuddin, Golam
Smith, Thomas
Gonzalez, Ernesto
Su, Li
Christiani, David C
author_sort McCarty, Kathleen M
collection PubMed
description BACKGROUND: Polymorphisms in GSTT1, GSTM1 and GSTP1 impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic biotransformation may influence disease susceptibility. GST activity is involved in the metabolism of endogenous and exogenous compounds, including catalyzing the formation of arsenic-GSH conjugates. METHODS: We investigated whether polymorphisms in GSTT1, GSTP1 and GSTM1 were associated with risk of skin lesions and whether these polymorphisms modify the relationship between drinking water arsenic exposure and skin lesions in a case control study of 1200 subjects frequency matched on age and gender in community clinics in Pabna, Bangladesh in 2001–2002. RESULTS AND DISCUSSION: GSTT1 homozygous wildtype status was associated with increased odds of skin lesions compared to the null status (OR1.56 95% CI 1.10–2.19). The GSTP1 GG polymorphism was associated with greater odds of skin lesions compared to GSTP1 AA, (OR 1.86 (95%CI 1.15–3.00). No evidence of effect modification by GSTT1, GSTM1 or GSTP1 polymorphisms on the association between arsenic exposure and skin lesions was detected. CONCLUSION: GSTT1 wildtype and GSTP1 GG are associated with increased risk of skin lesions.
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spelling pubmed-18054332007-02-27 A case-control study of GST polymorphisms and arsenic related skin lesions McCarty, Kathleen M Ryan, Louise Houseman, E Andres Williams, Paige L Miller, David P Quamruzzaman, Quazi Rahman, Mahmuder Mahiuddin, Golam Smith, Thomas Gonzalez, Ernesto Su, Li Christiani, David C Environ Health Research BACKGROUND: Polymorphisms in GSTT1, GSTM1 and GSTP1 impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic biotransformation may influence disease susceptibility. GST activity is involved in the metabolism of endogenous and exogenous compounds, including catalyzing the formation of arsenic-GSH conjugates. METHODS: We investigated whether polymorphisms in GSTT1, GSTP1 and GSTM1 were associated with risk of skin lesions and whether these polymorphisms modify the relationship between drinking water arsenic exposure and skin lesions in a case control study of 1200 subjects frequency matched on age and gender in community clinics in Pabna, Bangladesh in 2001–2002. RESULTS AND DISCUSSION: GSTT1 homozygous wildtype status was associated with increased odds of skin lesions compared to the null status (OR1.56 95% CI 1.10–2.19). The GSTP1 GG polymorphism was associated with greater odds of skin lesions compared to GSTP1 AA, (OR 1.86 (95%CI 1.15–3.00). No evidence of effect modification by GSTT1, GSTM1 or GSTP1 polymorphisms on the association between arsenic exposure and skin lesions was detected. CONCLUSION: GSTT1 wildtype and GSTP1 GG are associated with increased risk of skin lesions. BioMed Central 2007-02-06 /pmc/articles/PMC1805433/ /pubmed/17284320 http://dx.doi.org/10.1186/1476-069X-6-5 Text en Copyright © 2007 McCarty et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
McCarty, Kathleen M
Ryan, Louise
Houseman, E Andres
Williams, Paige L
Miller, David P
Quamruzzaman, Quazi
Rahman, Mahmuder
Mahiuddin, Golam
Smith, Thomas
Gonzalez, Ernesto
Su, Li
Christiani, David C
A case-control study of GST polymorphisms and arsenic related skin lesions
title A case-control study of GST polymorphisms and arsenic related skin lesions
title_full A case-control study of GST polymorphisms and arsenic related skin lesions
title_fullStr A case-control study of GST polymorphisms and arsenic related skin lesions
title_full_unstemmed A case-control study of GST polymorphisms and arsenic related skin lesions
title_short A case-control study of GST polymorphisms and arsenic related skin lesions
title_sort case-control study of gst polymorphisms and arsenic related skin lesions
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805433/
https://www.ncbi.nlm.nih.gov/pubmed/17284320
http://dx.doi.org/10.1186/1476-069X-6-5
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